6QZR

14-3-3 sigma in complex with FOXO1 pT24 peptide

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0001836	biological_process	release of cytochrome c from mitochondria
A	0005515	molecular_function	protein binding
A	0005576	cellular_component	extracellular region
A	0005615	cellular_component	extracellular space
A	0005634	cellular_component	nucleus
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0006469	biological_process	negative regulation of protein kinase activity
A	0006611	biological_process	protein export from nucleus
A	0007165	biological_process	signal transduction
A	0008104	biological_process	intracellular protein localization
A	0008426	molecular_function	protein kinase C inhibitor activity
A	0008630	biological_process	intrinsic apoptotic signaling pathway in response to DNA damage
A	0010482	biological_process	regulation of epidermal cell division
A	0019901	molecular_function	protein kinase binding
A	0022407	biological_process	regulation of cell-cell adhesion
A	0030307	biological_process	positive regulation of cell growth
A	0032880	biological_process	regulation of protein localization
A	0042802	molecular_function	identical protein binding
A	0045296	molecular_function	cadherin binding
A	0045606	biological_process	positive regulation of epidermal cell differentiation
A	0045785	biological_process	positive regulation of cell adhesion
A	0045824	biological_process	negative regulation of innate immune response
A	0046827	biological_process	positive regulation of protein export from nucleus
A	0050815	molecular_function	phosphoserine residue binding
A	0051219	molecular_function	phosphoprotein binding
A	0061436	biological_process	establishment of skin barrier
A	0070062	cellular_component	extracellular exosome
A	0140311	molecular_function	protein sequestering activity
A	0141156	biological_process	cAMP/PKA signal transduction
A	1903077	biological_process	negative regulation of protein localization to plasma membrane
A	1903829	biological_process	positive regulation of protein localization
B	0001836	biological_process	release of cytochrome c from mitochondria
B	0005515	molecular_function	protein binding
B	0005576	cellular_component	extracellular region
B	0005615	cellular_component	extracellular space
B	0005634	cellular_component	nucleus
B	0005737	cellular_component	cytoplasm
B	0005829	cellular_component	cytosol
B	0006469	biological_process	negative regulation of protein kinase activity
B	0006611	biological_process	protein export from nucleus
B	0007165	biological_process	signal transduction
B	0008104	biological_process	intracellular protein localization
B	0008426	molecular_function	protein kinase C inhibitor activity
B	0008630	biological_process	intrinsic apoptotic signaling pathway in response to DNA damage
B	0010482	biological_process	regulation of epidermal cell division
B	0019901	molecular_function	protein kinase binding
B	0022407	biological_process	regulation of cell-cell adhesion
B	0030307	biological_process	positive regulation of cell growth
B	0032880	biological_process	regulation of protein localization
B	0042802	molecular_function	identical protein binding
B	0045296	molecular_function	cadherin binding
B	0045606	biological_process	positive regulation of epidermal cell differentiation
B	0045785	biological_process	positive regulation of cell adhesion
B	0045824	biological_process	negative regulation of innate immune response
B	0046827	biological_process	positive regulation of protein export from nucleus
B	0050815	molecular_function	phosphoserine residue binding
B	0051219	molecular_function	phosphoprotein binding
B	0061436	biological_process	establishment of skin barrier
B	0070062	cellular_component	extracellular exosome
B	0140311	molecular_function	protein sequestering activity
B	0141156	biological_process	cAMP/PKA signal transduction
B	1903077	biological_process	negative regulation of protein localization to plasma membrane
B	1903829	biological_process	positive regulation of protein localization
C	0001836	biological_process	release of cytochrome c from mitochondria
C	0005515	molecular_function	protein binding
C	0005576	cellular_component	extracellular region
C	0005615	cellular_component	extracellular space
C	0005634	cellular_component	nucleus
C	0005737	cellular_component	cytoplasm
C	0005829	cellular_component	cytosol
C	0006469	biological_process	negative regulation of protein kinase activity
C	0006611	biological_process	protein export from nucleus
C	0007165	biological_process	signal transduction
C	0008104	biological_process	intracellular protein localization
C	0008426	molecular_function	protein kinase C inhibitor activity
C	0008630	biological_process	intrinsic apoptotic signaling pathway in response to DNA damage
C	0010482	biological_process	regulation of epidermal cell division
C	0019901	molecular_function	protein kinase binding
C	0022407	biological_process	regulation of cell-cell adhesion
C	0030307	biological_process	positive regulation of cell growth
C	0032880	biological_process	regulation of protein localization
C	0042802	molecular_function	identical protein binding
C	0045296	molecular_function	cadherin binding
C	0045606	biological_process	positive regulation of epidermal cell differentiation
C	0045785	biological_process	positive regulation of cell adhesion
C	0045824	biological_process	negative regulation of innate immune response
C	0046827	biological_process	positive regulation of protein export from nucleus
C	0050815	molecular_function	phosphoserine residue binding
C	0051219	molecular_function	phosphoprotein binding
C	0061436	biological_process	establishment of skin barrier
C	0070062	cellular_component	extracellular exosome
C	0140311	molecular_function	protein sequestering activity
C	0141156	biological_process	cAMP/PKA signal transduction
C	1903077	biological_process	negative regulation of protein localization to plasma membrane
C	1903829	biological_process	positive regulation of protein localization
D	0001836	biological_process	release of cytochrome c from mitochondria
D	0005515	molecular_function	protein binding
D	0005576	cellular_component	extracellular region
D	0005615	cellular_component	extracellular space
D	0005634	cellular_component	nucleus
D	0005737	cellular_component	cytoplasm
D	0005829	cellular_component	cytosol
D	0006469	biological_process	negative regulation of protein kinase activity
D	0006611	biological_process	protein export from nucleus
D	0007165	biological_process	signal transduction
D	0008104	biological_process	intracellular protein localization
D	0008426	molecular_function	protein kinase C inhibitor activity
D	0008630	biological_process	intrinsic apoptotic signaling pathway in response to DNA damage
D	0010482	biological_process	regulation of epidermal cell division
D	0019901	molecular_function	protein kinase binding
D	0022407	biological_process	regulation of cell-cell adhesion
D	0030307	biological_process	positive regulation of cell growth
D	0032880	biological_process	regulation of protein localization
D	0042802	molecular_function	identical protein binding
D	0045296	molecular_function	cadherin binding
D	0045606	biological_process	positive regulation of epidermal cell differentiation
D	0045785	biological_process	positive regulation of cell adhesion
D	0045824	biological_process	negative regulation of innate immune response
D	0046827	biological_process	positive regulation of protein export from nucleus
D	0050815	molecular_function	phosphoserine residue binding
D	0051219	molecular_function	phosphoprotein binding
D	0061436	biological_process	establishment of skin barrier
D	0070062	cellular_component	extracellular exosome
D	0140311	molecular_function	protein sequestering activity
D	0141156	biological_process	cAMP/PKA signal transduction
D	1903077	biological_process	negative regulation of protein localization to plasma membrane
D	1903829	biological_process	positive regulation of protein localization
E	0001836	biological_process	release of cytochrome c from mitochondria
E	0005515	molecular_function	protein binding
E	0005576	cellular_component	extracellular region
E	0005615	cellular_component	extracellular space
E	0005634	cellular_component	nucleus
E	0005737	cellular_component	cytoplasm
E	0005829	cellular_component	cytosol
E	0006469	biological_process	negative regulation of protein kinase activity
E	0006611	biological_process	protein export from nucleus
E	0007165	biological_process	signal transduction
E	0008104	biological_process	intracellular protein localization
E	0008426	molecular_function	protein kinase C inhibitor activity
E	0008630	biological_process	intrinsic apoptotic signaling pathway in response to DNA damage
E	0010482	biological_process	regulation of epidermal cell division
E	0019901	molecular_function	protein kinase binding
E	0022407	biological_process	regulation of cell-cell adhesion
E	0030307	biological_process	positive regulation of cell growth
E	0032880	biological_process	regulation of protein localization
E	0042802	molecular_function	identical protein binding
E	0045296	molecular_function	cadherin binding
E	0045606	biological_process	positive regulation of epidermal cell differentiation
E	0045785	biological_process	positive regulation of cell adhesion
E	0045824	biological_process	negative regulation of innate immune response
E	0046827	biological_process	positive regulation of protein export from nucleus
E	0050815	molecular_function	phosphoserine residue binding
E	0051219	molecular_function	phosphoprotein binding
E	0061436	biological_process	establishment of skin barrier
E	0070062	cellular_component	extracellular exosome
E	0140311	molecular_function	protein sequestering activity
E	0141156	biological_process	cAMP/PKA signal transduction
E	1903077	biological_process	negative regulation of protein localization to plasma membrane
E	1903829	biological_process	positive regulation of protein localization
F	0001836	biological_process	release of cytochrome c from mitochondria
F	0005515	molecular_function	protein binding
F	0005576	cellular_component	extracellular region
F	0005615	cellular_component	extracellular space
F	0005634	cellular_component	nucleus
F	0005737	cellular_component	cytoplasm
F	0005829	cellular_component	cytosol
F	0006469	biological_process	negative regulation of protein kinase activity
F	0006611	biological_process	protein export from nucleus
F	0007165	biological_process	signal transduction
F	0008104	biological_process	intracellular protein localization
F	0008426	molecular_function	protein kinase C inhibitor activity
F	0008630	biological_process	intrinsic apoptotic signaling pathway in response to DNA damage
F	0010482	biological_process	regulation of epidermal cell division
F	0019901	molecular_function	protein kinase binding
F	0022407	biological_process	regulation of cell-cell adhesion
F	0030307	biological_process	positive regulation of cell growth
F	0032880	biological_process	regulation of protein localization
F	0042802	molecular_function	identical protein binding
F	0045296	molecular_function	cadherin binding
F	0045606	biological_process	positive regulation of epidermal cell differentiation
F	0045785	biological_process	positive regulation of cell adhesion
F	0045824	biological_process	negative regulation of innate immune response
F	0046827	biological_process	positive regulation of protein export from nucleus
F	0050815	molecular_function	phosphoserine residue binding
F	0051219	molecular_function	phosphoprotein binding
F	0061436	biological_process	establishment of skin barrier
F	0070062	cellular_component	extracellular exosome
F	0140311	molecular_function	protein sequestering activity
F	0141156	biological_process	cAMP/PKA signal transduction
F	1903077	biological_process	negative regulation of protein localization to plasma membrane
F	1903829	biological_process	positive regulation of protein localization
G	0001836	biological_process	release of cytochrome c from mitochondria
G	0005515	molecular_function	protein binding
G	0005576	cellular_component	extracellular region
G	0005615	cellular_component	extracellular space
G	0005634	cellular_component	nucleus
G	0005737	cellular_component	cytoplasm
G	0005829	cellular_component	cytosol
G	0006469	biological_process	negative regulation of protein kinase activity
G	0006611	biological_process	protein export from nucleus
G	0007165	biological_process	signal transduction
G	0008104	biological_process	intracellular protein localization
G	0008426	molecular_function	protein kinase C inhibitor activity
G	0008630	biological_process	intrinsic apoptotic signaling pathway in response to DNA damage
G	0010482	biological_process	regulation of epidermal cell division
G	0019901	molecular_function	protein kinase binding
G	0022407	biological_process	regulation of cell-cell adhesion
G	0030307	biological_process	positive regulation of cell growth
G	0032880	biological_process	regulation of protein localization
G	0042802	molecular_function	identical protein binding
G	0045296	molecular_function	cadherin binding
G	0045606	biological_process	positive regulation of epidermal cell differentiation
G	0045785	biological_process	positive regulation of cell adhesion
G	0045824	biological_process	negative regulation of innate immune response
G	0046827	biological_process	positive regulation of protein export from nucleus
G	0050815	molecular_function	phosphoserine residue binding
G	0051219	molecular_function	phosphoprotein binding
G	0061436	biological_process	establishment of skin barrier
G	0070062	cellular_component	extracellular exosome
G	0140311	molecular_function	protein sequestering activity
G	0141156	biological_process	cAMP/PKA signal transduction
G	1903077	biological_process	negative regulation of protein localization to plasma membrane
G	1903829	biological_process	positive regulation of protein localization
H	0001836	biological_process	release of cytochrome c from mitochondria
H	0005515	molecular_function	protein binding
H	0005576	cellular_component	extracellular region
H	0005615	cellular_component	extracellular space
H	0005634	cellular_component	nucleus
H	0005737	cellular_component	cytoplasm
H	0005829	cellular_component	cytosol
H	0006469	biological_process	negative regulation of protein kinase activity
H	0006611	biological_process	protein export from nucleus
H	0007165	biological_process	signal transduction
H	0008104	biological_process	intracellular protein localization
H	0008426	molecular_function	protein kinase C inhibitor activity
H	0008630	biological_process	intrinsic apoptotic signaling pathway in response to DNA damage
H	0010482	biological_process	regulation of epidermal cell division
H	0019901	molecular_function	protein kinase binding
H	0022407	biological_process	regulation of cell-cell adhesion
H	0030307	biological_process	positive regulation of cell growth
H	0032880	biological_process	regulation of protein localization
H	0042802	molecular_function	identical protein binding
H	0045296	molecular_function	cadherin binding
H	0045606	biological_process	positive regulation of epidermal cell differentiation
H	0045785	biological_process	positive regulation of cell adhesion
H	0045824	biological_process	negative regulation of innate immune response
H	0046827	biological_process	positive regulation of protein export from nucleus
H	0050815	molecular_function	phosphoserine residue binding
H	0051219	molecular_function	phosphoprotein binding
H	0061436	biological_process	establishment of skin barrier
H	0070062	cellular_component	extracellular exosome
H	0140311	molecular_function	protein sequestering activity
H	0141156	biological_process	cAMP/PKA signal transduction
H	1903077	biological_process	negative regulation of protein localization to plasma membrane
H	1903829	biological_process	positive regulation of protein localization

Functional Information from PDB Data

site_id	AC1
Number of Residues	11
Details	binding site for residue B3P A 301

Chain	Residue
A	GLN93
C	ASP139
C	ILE143
A	ASP97
A	ASP139
A	ILE143
A	HOH412
A	HOH417
A	HOH466
C	GLN93
C	ASP97

---

site_id	AC2
Number of Residues	5
Details	binding site for residue GOL A 302

Chain	Residue
A	GLU2
A	ARG3
A	GOL303
A	HOH407
C	GLU2

---

site_id	AC3
Number of Residues	6
Details	binding site for residue GOL A 303

Chain	Residue
A	GLU2
A	GOL302
A	HOH449
C	GLU2
C	ARG3
C	GLU34

---

site_id	AC4
Number of Residues	7
Details	binding site for residue B3P B 301

Chain	Residue
B	GLN93
B	ASP97
B	ASP139
D	GLN93
D	ASP97
D	ASP139
D	ARG142

---

site_id	AC5
Number of Residues	5
Details	binding site for residue GOL D 301

Chain	Residue
B	GLU2
B	ARG3
B	GLU34
D	GLU2
D	GOL302

---

site_id	AC6
Number of Residues	3
Details	binding site for residue GOL D 302

Chain	Residue
B	GLU2
D	GLU34
D	GOL301

---

site_id	AC7
Number of Residues	7
Details	binding site for residue B3P F 301

Chain	Residue
F	GLN93
F	ASP97
F	ASP139
F	HOH482
G	GLN93
G	ASP97
G	ASP139

---

site_id	AC8
Number of Residues	8
Details	binding site for residue B3P H 301

Chain	Residue
E	GLN93
E	ASP97
E	ASP139
H	GLN93
H	ASP97
H	ASP139
H	ILE143
H	HOH438

---

site_id	AC9
Number of Residues	3
Details	binding site for residue GOL H 302

Chain	Residue
E	GLU34
H	GLU2
H	GOL303

---

site_id	AD1
Number of Residues	5
Details	binding site for residue GOL H 303

Chain	Residue
E	GLU2
H	GLU2
H	ARG3
H	GLU34
H	GOL302

---

site_id	AD2
Number of Residues	4
Details	binding site for residue GOL G 301

Chain	Residue
F	GLU34
G	GLU2
G	HOH407
G	HOH427

---

Functional Information from PROSITE/UniProt

site_id	PS00796
Number of Residues	11
Details	1433_1 14-3-3 proteins signature 1. RNLLSVAYKNV

Chain	Residue	Details
A	ARG41-VAL51

---

site_id	PS00797
Number of Residues	20
Details	1433_2 14-3-3 proteins signature 2. YKDSTLIMQLLRDNLTLWTA

Chain	Residue	Details
A	TYR213-ALA232

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	16
Details	Site: {"description":"Interaction with phosphoserine on interacting protein"}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	8
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"20068231","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	8
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	8
Details	Modified residue: {"description":"Phosphothreonine; by PKB/AKT1 or PKB/AKT2 and SGK1","evidences":[{"source":"PubMed","id":"10358075","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"11237865","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"11980723","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---