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6QZR

14-3-3 sigma in complex with FOXO1 pT24 peptide

Functional Information from GO Data
ChainGOidnamespacecontents
A0000122biological_processnegative regulation of transcription by RNA polymerase II
A0001836biological_processrelease of cytochrome c from mitochondria
A0003334biological_processkeratinocyte development
A0005515molecular_functionprotein binding
A0005576cellular_componentextracellular region
A0005615cellular_componentextracellular space
A0005634cellular_componentnucleus
A0005737cellular_componentcytoplasm
A0005829cellular_componentcytosol
A0006469biological_processnegative regulation of protein kinase activity
A0006611biological_processprotein export from nucleus
A0007165biological_processsignal transduction
A0008104biological_processprotein localization
A0008426molecular_functionprotein kinase C inhibitor activity
A0008630biological_processintrinsic apoptotic signaling pathway in response to DNA damage
A0010482biological_processregulation of epidermal cell division
A0010839biological_processnegative regulation of keratinocyte proliferation
A0019901molecular_functionprotein kinase binding
A0022407biological_processregulation of cell-cell adhesion
A0030216biological_processkeratinocyte differentiation
A0030307biological_processpositive regulation of cell growth
A0031424biological_processkeratinization
A0032880biological_processregulation of protein localization
A0042742biological_processdefense response to bacterium
A0042802molecular_functionidentical protein binding
A0043588biological_processskin development
A0043616biological_processkeratinocyte proliferation
A0045296molecular_functioncadherin binding
A0045606biological_processpositive regulation of epidermal cell differentiation
A0045785biological_processpositive regulation of cell adhesion
A0045824biological_processnegative regulation of innate immune response
A0046827biological_processpositive regulation of protein export from nucleus
A0050815molecular_functionphosphoserine residue binding
A0051219molecular_functionphosphoprotein binding
A0051715biological_processcytolysis in another organism
A0051726biological_processregulation of cell cycle
A0061436biological_processestablishment of skin barrier
A0070062cellular_componentextracellular exosome
A0072089biological_processstem cell proliferation
A0140311molecular_functionprotein sequestering activity
A0141156biological_processcAMP/PKA signal transduction
A0160075biological_processnon-canonical inflammasome complex assembly
A1903077biological_processnegative regulation of protein localization to plasma membrane
A1903829biological_processpositive regulation of protein localization
A2000647biological_processnegative regulation of stem cell proliferation
B0000122biological_processnegative regulation of transcription by RNA polymerase II
B0001836biological_processrelease of cytochrome c from mitochondria
B0003334biological_processkeratinocyte development
B0005515molecular_functionprotein binding
B0005576cellular_componentextracellular region
B0005615cellular_componentextracellular space
B0005634cellular_componentnucleus
B0005737cellular_componentcytoplasm
B0005829cellular_componentcytosol
B0006469biological_processnegative regulation of protein kinase activity
B0006611biological_processprotein export from nucleus
B0007165biological_processsignal transduction
B0008104biological_processprotein localization
B0008426molecular_functionprotein kinase C inhibitor activity
B0008630biological_processintrinsic apoptotic signaling pathway in response to DNA damage
B0010482biological_processregulation of epidermal cell division
B0010839biological_processnegative regulation of keratinocyte proliferation
B0019901molecular_functionprotein kinase binding
B0022407biological_processregulation of cell-cell adhesion
B0030216biological_processkeratinocyte differentiation
B0030307biological_processpositive regulation of cell growth
B0031424biological_processkeratinization
B0032880biological_processregulation of protein localization
B0042742biological_processdefense response to bacterium
B0042802molecular_functionidentical protein binding
B0043588biological_processskin development
B0043616biological_processkeratinocyte proliferation
B0045296molecular_functioncadherin binding
B0045606biological_processpositive regulation of epidermal cell differentiation
B0045785biological_processpositive regulation of cell adhesion
B0045824biological_processnegative regulation of innate immune response
B0046827biological_processpositive regulation of protein export from nucleus
B0050815molecular_functionphosphoserine residue binding
B0051219molecular_functionphosphoprotein binding
B0051715biological_processcytolysis in another organism
B0051726biological_processregulation of cell cycle
B0061436biological_processestablishment of skin barrier
B0070062cellular_componentextracellular exosome
B0072089biological_processstem cell proliferation
B0140311molecular_functionprotein sequestering activity
B0141156biological_processcAMP/PKA signal transduction
B0160075biological_processnon-canonical inflammasome complex assembly
B1903077biological_processnegative regulation of protein localization to plasma membrane
B1903829biological_processpositive regulation of protein localization
B2000647biological_processnegative regulation of stem cell proliferation
C0000122biological_processnegative regulation of transcription by RNA polymerase II
C0001836biological_processrelease of cytochrome c from mitochondria
C0003334biological_processkeratinocyte development
C0005515molecular_functionprotein binding
C0005576cellular_componentextracellular region
C0005615cellular_componentextracellular space
C0005634cellular_componentnucleus
C0005737cellular_componentcytoplasm
C0005829cellular_componentcytosol
C0006469biological_processnegative regulation of protein kinase activity
C0006611biological_processprotein export from nucleus
C0007165biological_processsignal transduction
C0008104biological_processprotein localization
C0008426molecular_functionprotein kinase C inhibitor activity
C0008630biological_processintrinsic apoptotic signaling pathway in response to DNA damage
C0010482biological_processregulation of epidermal cell division
C0010839biological_processnegative regulation of keratinocyte proliferation
C0019901molecular_functionprotein kinase binding
C0022407biological_processregulation of cell-cell adhesion
C0030216biological_processkeratinocyte differentiation
C0030307biological_processpositive regulation of cell growth
C0031424biological_processkeratinization
C0032880biological_processregulation of protein localization
C0042742biological_processdefense response to bacterium
C0042802molecular_functionidentical protein binding
C0043588biological_processskin development
C0043616biological_processkeratinocyte proliferation
C0045296molecular_functioncadherin binding
C0045606biological_processpositive regulation of epidermal cell differentiation
C0045785biological_processpositive regulation of cell adhesion
C0045824biological_processnegative regulation of innate immune response
C0046827biological_processpositive regulation of protein export from nucleus
C0050815molecular_functionphosphoserine residue binding
C0051219molecular_functionphosphoprotein binding
C0051715biological_processcytolysis in another organism
C0051726biological_processregulation of cell cycle
C0061436biological_processestablishment of skin barrier
C0070062cellular_componentextracellular exosome
C0072089biological_processstem cell proliferation
C0140311molecular_functionprotein sequestering activity
C0141156biological_processcAMP/PKA signal transduction
C0160075biological_processnon-canonical inflammasome complex assembly
C1903077biological_processnegative regulation of protein localization to plasma membrane
C1903829biological_processpositive regulation of protein localization
C2000647biological_processnegative regulation of stem cell proliferation
D0000122biological_processnegative regulation of transcription by RNA polymerase II
D0001836biological_processrelease of cytochrome c from mitochondria
D0003334biological_processkeratinocyte development
D0005515molecular_functionprotein binding
D0005576cellular_componentextracellular region
D0005615cellular_componentextracellular space
D0005634cellular_componentnucleus
D0005737cellular_componentcytoplasm
D0005829cellular_componentcytosol
D0006469biological_processnegative regulation of protein kinase activity
D0006611biological_processprotein export from nucleus
D0007165biological_processsignal transduction
D0008104biological_processprotein localization
D0008426molecular_functionprotein kinase C inhibitor activity
D0008630biological_processintrinsic apoptotic signaling pathway in response to DNA damage
D0010482biological_processregulation of epidermal cell division
D0010839biological_processnegative regulation of keratinocyte proliferation
D0019901molecular_functionprotein kinase binding
D0022407biological_processregulation of cell-cell adhesion
D0030216biological_processkeratinocyte differentiation
D0030307biological_processpositive regulation of cell growth
D0031424biological_processkeratinization
D0032880biological_processregulation of protein localization
D0042742biological_processdefense response to bacterium
D0042802molecular_functionidentical protein binding
D0043588biological_processskin development
D0043616biological_processkeratinocyte proliferation
D0045296molecular_functioncadherin binding
D0045606biological_processpositive regulation of epidermal cell differentiation
D0045785biological_processpositive regulation of cell adhesion
D0045824biological_processnegative regulation of innate immune response
D0046827biological_processpositive regulation of protein export from nucleus
D0050815molecular_functionphosphoserine residue binding
D0051219molecular_functionphosphoprotein binding
D0051715biological_processcytolysis in another organism
D0051726biological_processregulation of cell cycle
D0061436biological_processestablishment of skin barrier
D0070062cellular_componentextracellular exosome
D0072089biological_processstem cell proliferation
D0140311molecular_functionprotein sequestering activity
D0141156biological_processcAMP/PKA signal transduction
D0160075biological_processnon-canonical inflammasome complex assembly
D1903077biological_processnegative regulation of protein localization to plasma membrane
D1903829biological_processpositive regulation of protein localization
D2000647biological_processnegative regulation of stem cell proliferation
E0000122biological_processnegative regulation of transcription by RNA polymerase II
E0001836biological_processrelease of cytochrome c from mitochondria
E0003334biological_processkeratinocyte development
E0005515molecular_functionprotein binding
E0005576cellular_componentextracellular region
E0005615cellular_componentextracellular space
E0005634cellular_componentnucleus
E0005737cellular_componentcytoplasm
E0005829cellular_componentcytosol
E0006469biological_processnegative regulation of protein kinase activity
E0006611biological_processprotein export from nucleus
E0007165biological_processsignal transduction
E0008104biological_processprotein localization
E0008426molecular_functionprotein kinase C inhibitor activity
E0008630biological_processintrinsic apoptotic signaling pathway in response to DNA damage
E0010482biological_processregulation of epidermal cell division
E0010839biological_processnegative regulation of keratinocyte proliferation
E0019901molecular_functionprotein kinase binding
E0022407biological_processregulation of cell-cell adhesion
E0030216biological_processkeratinocyte differentiation
E0030307biological_processpositive regulation of cell growth
E0031424biological_processkeratinization
E0032880biological_processregulation of protein localization
E0042742biological_processdefense response to bacterium
E0042802molecular_functionidentical protein binding
E0043588biological_processskin development
E0043616biological_processkeratinocyte proliferation
E0045296molecular_functioncadherin binding
E0045606biological_processpositive regulation of epidermal cell differentiation
E0045785biological_processpositive regulation of cell adhesion
E0045824biological_processnegative regulation of innate immune response
E0046827biological_processpositive regulation of protein export from nucleus
E0050815molecular_functionphosphoserine residue binding
E0051219molecular_functionphosphoprotein binding
E0051715biological_processcytolysis in another organism
E0051726biological_processregulation of cell cycle
E0061436biological_processestablishment of skin barrier
E0070062cellular_componentextracellular exosome
E0072089biological_processstem cell proliferation
E0140311molecular_functionprotein sequestering activity
E0141156biological_processcAMP/PKA signal transduction
E0160075biological_processnon-canonical inflammasome complex assembly
E1903077biological_processnegative regulation of protein localization to plasma membrane
E1903829biological_processpositive regulation of protein localization
E2000647biological_processnegative regulation of stem cell proliferation
F0000122biological_processnegative regulation of transcription by RNA polymerase II
F0001836biological_processrelease of cytochrome c from mitochondria
F0003334biological_processkeratinocyte development
F0005515molecular_functionprotein binding
F0005576cellular_componentextracellular region
F0005615cellular_componentextracellular space
F0005634cellular_componentnucleus
F0005737cellular_componentcytoplasm
F0005829cellular_componentcytosol
F0006469biological_processnegative regulation of protein kinase activity
F0006611biological_processprotein export from nucleus
F0007165biological_processsignal transduction
F0008104biological_processprotein localization
F0008426molecular_functionprotein kinase C inhibitor activity
F0008630biological_processintrinsic apoptotic signaling pathway in response to DNA damage
F0010482biological_processregulation of epidermal cell division
F0010839biological_processnegative regulation of keratinocyte proliferation
F0019901molecular_functionprotein kinase binding
F0022407biological_processregulation of cell-cell adhesion
F0030216biological_processkeratinocyte differentiation
F0030307biological_processpositive regulation of cell growth
F0031424biological_processkeratinization
F0032880biological_processregulation of protein localization
F0042742biological_processdefense response to bacterium
F0042802molecular_functionidentical protein binding
F0043588biological_processskin development
F0043616biological_processkeratinocyte proliferation
F0045296molecular_functioncadherin binding
F0045606biological_processpositive regulation of epidermal cell differentiation
F0045785biological_processpositive regulation of cell adhesion
F0045824biological_processnegative regulation of innate immune response
F0046827biological_processpositive regulation of protein export from nucleus
F0050815molecular_functionphosphoserine residue binding
F0051219molecular_functionphosphoprotein binding
F0051715biological_processcytolysis in another organism
F0051726biological_processregulation of cell cycle
F0061436biological_processestablishment of skin barrier
F0070062cellular_componentextracellular exosome
F0072089biological_processstem cell proliferation
F0140311molecular_functionprotein sequestering activity
F0141156biological_processcAMP/PKA signal transduction
F0160075biological_processnon-canonical inflammasome complex assembly
F1903077biological_processnegative regulation of protein localization to plasma membrane
F1903829biological_processpositive regulation of protein localization
F2000647biological_processnegative regulation of stem cell proliferation
G0000122biological_processnegative regulation of transcription by RNA polymerase II
G0001836biological_processrelease of cytochrome c from mitochondria
G0003334biological_processkeratinocyte development
G0005515molecular_functionprotein binding
G0005576cellular_componentextracellular region
G0005615cellular_componentextracellular space
G0005634cellular_componentnucleus
G0005737cellular_componentcytoplasm
G0005829cellular_componentcytosol
G0006469biological_processnegative regulation of protein kinase activity
G0006611biological_processprotein export from nucleus
G0007165biological_processsignal transduction
G0008104biological_processprotein localization
G0008426molecular_functionprotein kinase C inhibitor activity
G0008630biological_processintrinsic apoptotic signaling pathway in response to DNA damage
G0010482biological_processregulation of epidermal cell division
G0010839biological_processnegative regulation of keratinocyte proliferation
G0019901molecular_functionprotein kinase binding
G0022407biological_processregulation of cell-cell adhesion
G0030216biological_processkeratinocyte differentiation
G0030307biological_processpositive regulation of cell growth
G0031424biological_processkeratinization
G0032880biological_processregulation of protein localization
G0042742biological_processdefense response to bacterium
G0042802molecular_functionidentical protein binding
G0043588biological_processskin development
G0043616biological_processkeratinocyte proliferation
G0045296molecular_functioncadherin binding
G0045606biological_processpositive regulation of epidermal cell differentiation
G0045785biological_processpositive regulation of cell adhesion
G0045824biological_processnegative regulation of innate immune response
G0046827biological_processpositive regulation of protein export from nucleus
G0050815molecular_functionphosphoserine residue binding
G0051219molecular_functionphosphoprotein binding
G0051715biological_processcytolysis in another organism
G0051726biological_processregulation of cell cycle
G0061436biological_processestablishment of skin barrier
G0070062cellular_componentextracellular exosome
G0072089biological_processstem cell proliferation
G0140311molecular_functionprotein sequestering activity
G0141156biological_processcAMP/PKA signal transduction
G0160075biological_processnon-canonical inflammasome complex assembly
G1903077biological_processnegative regulation of protein localization to plasma membrane
G1903829biological_processpositive regulation of protein localization
G2000647biological_processnegative regulation of stem cell proliferation
H0000122biological_processnegative regulation of transcription by RNA polymerase II
H0001836biological_processrelease of cytochrome c from mitochondria
H0003334biological_processkeratinocyte development
H0005515molecular_functionprotein binding
H0005576cellular_componentextracellular region
H0005615cellular_componentextracellular space
H0005634cellular_componentnucleus
H0005737cellular_componentcytoplasm
H0005829cellular_componentcytosol
H0006469biological_processnegative regulation of protein kinase activity
H0006611biological_processprotein export from nucleus
H0007165biological_processsignal transduction
H0008104biological_processprotein localization
H0008426molecular_functionprotein kinase C inhibitor activity
H0008630biological_processintrinsic apoptotic signaling pathway in response to DNA damage
H0010482biological_processregulation of epidermal cell division
H0010839biological_processnegative regulation of keratinocyte proliferation
H0019901molecular_functionprotein kinase binding
H0022407biological_processregulation of cell-cell adhesion
H0030216biological_processkeratinocyte differentiation
H0030307biological_processpositive regulation of cell growth
H0031424biological_processkeratinization
H0032880biological_processregulation of protein localization
H0042742biological_processdefense response to bacterium
H0042802molecular_functionidentical protein binding
H0043588biological_processskin development
H0043616biological_processkeratinocyte proliferation
H0045296molecular_functioncadherin binding
H0045606biological_processpositive regulation of epidermal cell differentiation
H0045785biological_processpositive regulation of cell adhesion
H0045824biological_processnegative regulation of innate immune response
H0046827biological_processpositive regulation of protein export from nucleus
H0050815molecular_functionphosphoserine residue binding
H0051219molecular_functionphosphoprotein binding
H0051715biological_processcytolysis in another organism
H0051726biological_processregulation of cell cycle
H0061436biological_processestablishment of skin barrier
H0070062cellular_componentextracellular exosome
H0072089biological_processstem cell proliferation
H0140311molecular_functionprotein sequestering activity
H0141156biological_processcAMP/PKA signal transduction
H0160075biological_processnon-canonical inflammasome complex assembly
H1903077biological_processnegative regulation of protein localization to plasma membrane
H1903829biological_processpositive regulation of protein localization
H2000647biological_processnegative regulation of stem cell proliferation
Functional Information from PDB Data
site_idAC1
Number of Residues11
Detailsbinding site for residue B3P A 301
ChainResidue
AGLN93
CASP139
CILE143
AASP97
AASP139
AILE143
AHOH412
AHOH417
AHOH466
CGLN93
CASP97

site_idAC2
Number of Residues5
Detailsbinding site for residue GOL A 302
ChainResidue
AGLU2
AARG3
AGOL303
AHOH407
CGLU2

site_idAC3
Number of Residues6
Detailsbinding site for residue GOL A 303
ChainResidue
AGLU2
AGOL302
AHOH449
CGLU2
CARG3
CGLU34

site_idAC4
Number of Residues7
Detailsbinding site for residue B3P B 301
ChainResidue
BGLN93
BASP97
BASP139
DGLN93
DASP97
DASP139
DARG142

site_idAC5
Number of Residues5
Detailsbinding site for residue GOL D 301
ChainResidue
BGLU2
BARG3
BGLU34
DGLU2
DGOL302

site_idAC6
Number of Residues3
Detailsbinding site for residue GOL D 302
ChainResidue
BGLU2
DGLU34
DGOL301

site_idAC7
Number of Residues7
Detailsbinding site for residue B3P F 301
ChainResidue
FGLN93
FASP97
FASP139
FHOH482
GGLN93
GASP97
GASP139

site_idAC8
Number of Residues8
Detailsbinding site for residue B3P H 301
ChainResidue
EGLN93
EASP97
EASP139
HGLN93
HASP97
HASP139
HILE143
HHOH438

site_idAC9
Number of Residues3
Detailsbinding site for residue GOL H 302
ChainResidue
EGLU34
HGLU2
HGOL303

site_idAD1
Number of Residues5
Detailsbinding site for residue GOL H 303
ChainResidue
EGLU2
HGLU2
HARG3
HGLU34
HGOL302

site_idAD2
Number of Residues4
Detailsbinding site for residue GOL G 301
ChainResidue
FGLU34
GGLU2
GHOH407
GHOH427

Functional Information from PROSITE/UniProt
site_idPS00796
Number of Residues11
Details1433_1 14-3-3 proteins signature 1. RNLLSVAYKNV
ChainResidueDetails
AARG41-VAL51

site_idPS00797
Number of Residues20
Details1433_2 14-3-3 proteins signature 2. YKDSTLIMQLLRDNLTLWTA
ChainResidueDetails
ATYR213-ALA232

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues8
DetailsMOD_RES: Phosphothreonine; by PKB/AKT1 or PKB/AKT2 and SGK1 => ECO:0000269|PubMed:10358075, ECO:0000269|PubMed:11237865, ECO:0000269|PubMed:11980723
ChainResidueDetails
RTPO24
EARG129
FARG56
FARG129
HARG56
HARG129
GARG56
GARG129
JTPO24
MTPO24
NTPO24
OTPO24
PTPO24
TTPO24
UTPO24
EARG56

site_idSWS_FT_FI2
Number of Residues8
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:20068231
ChainResidueDetails
ASER5
BSER5
CSER5
DSER5
ESER5
FSER5
HSER5
GSER5

site_idSWS_FT_FI3
Number of Residues8
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:23186163
ChainResidueDetails
ASER74
BSER74
CSER74
DSER74
ESER74
FSER74
HSER74
GSER74

site_idSWS_FT_FI4
Number of Residues8
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:16964243, ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:18691976, ECO:0007744|PubMed:20068231
ChainResidueDetails
ASER248
BSER248
CSER248
DSER248
ESER248
FSER248
HSER248
GSER248

237423

PDB entries from 2025-06-11

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