6QU9
Fab fragment of an antibody that inhibits polymerisation of alpha-1-antitrypsin
Summary for 6QU9
Entry DOI | 10.2210/pdb6qu9/pdb |
EMDB information | 4620 4631 4632 |
Descriptor | FAB 4B12 heavy chain, FAB 4B12 light chain, SULFATE ION, ... (6 entities in total) |
Functional Keywords | alpha-1 antitrypsin, z variant, polymers, protein aggregation, monoclonal antibody, fab fragment, copd, protease inhibitor, glycoprotein, deficiency, protein binding |
Biological source | Mus musculus (House mouse) More |
Total number of polymer chains | 4 |
Total formula weight | 94115.64 |
Authors | Jagger, A.M.,Heyer-Chauhan, N.,Lomas, D.A.,Irving, J.A. (deposition date: 2019-02-26, release date: 2020-03-18, Last modification date: 2024-05-01) |
Primary citation | Faull, S.V.,Elliston, E.L.K.,Gooptu, B.,Jagger, A.M.,Aldobiyan, I.,Redzej, A.,Badaoui, M.,Heyer-Chauhan, N.,Rashid, S.T.,Reynolds, G.M.,Adams, D.H.,Miranda, E.,Orlova, E.V.,Irving, J.A.,Lomas, D.A. The structural basis for Z alpha 1 -antitrypsin polymerization in the liver. Sci Adv, 6:-, 2020 Cited by PubMed: 33087346DOI: 10.1126/sciadv.abc1370 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.9 Å) |
Structure validation
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