6QU9

Fab fragment of an antibody that inhibits polymerisation of alpha-1-antitrypsin

6QU9 の概要

• エントリーDOI: 10.2210/pdb6qu9/pdb
• EMDBエントリー: 4620 4631 4632
• 分子名称: FAB 4B12 heavy chain, FAB 4B12 light chain, SULFATE ION, ... (6 entities in total)
• 機能のキーワード: alpha-1 antitrypsin, z variant, polymers, protein aggregation, monoclonal antibody, fab fragment, copd, protease inhibitor, glycoprotein, deficiency, protein binding
• 由来する生物種: Mus musculus (House mouse); 詳細
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 94115.64

構造登録者

Jagger, A.M.,Heyer-Chauhan, N.,Lomas, D.A.,Irving, J.A. (登録日: 2019-02-26, 公開日: 2020-03-18, 最終更新日: 2024-05-01)

• 主引用文献: Faull, S.V.,Elliston, E.L.K.,Gooptu, B.,Jagger, A.M.,Aldobiyan, I.,Redzej, A.,Badaoui, M.,Heyer-Chauhan, N.,Rashid, S.T.,Reynolds, G.M.,Adams, D.H.,Miranda, E.,Orlova, E.V.,Irving, J.A.,Lomas, D.A.; The structural basis for Z alpha 1 -antitrypsin polymerization in the liver.; Sci Adv, 6:-, 2020; PubMed: 33087346; DOI: 10.1126/sciadv.abc1370

実験手法

X-RAY DIFFRACTION (1.9 Å)