6QTP

2.37A structure of gepotidacin with S.aureus DNA gyrase and uncleaved DNA

Summary for 6QTP

• Entry DOI: 10.2210/pdb6qtp/pdb
• Related: 6QTK
• Descriptor: DNA gyrase subunit B,DNA gyrase subunit B, DNA gyrase subunit A, DNA (5'-D(*GP*AP*GP*CP*GP*TP*AP*CP*AP*GP*CP*TP*GP*TP*AP*CP*GP*CP*TP*T)-3'), ... (9 entities in total)
• Functional Keywords: inhibitor, dna, complex, isomerase
• Biological source: Staphylococcus aureus; More
• Total number of polymer chains: 6
• Total formula weight: 169355.50

Authors

Bax, B.D. (deposition date: 2019-02-25, release date: 2019-03-13, Last modification date: 2019-04-24)

• Primary citation: Gibson, E.G.,Bax, B.,Chan, P.F.,Osheroff, N.; Mechanistic and Structural Basis for the Actions of the Antibacterial Gepotidacin against Staphylococcus aureus Gyrase.; Acs Infect Dis., 5:570-581, 2019; PubMed: 30757898; DOI: 10.1021/acsinfecdis.8b00315

Experimental method

X-RAY DIFFRACTION (2.37 Å)