6QTP
2.37A structure of gepotidacin with S.aureus DNA gyrase and uncleaved DNA
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, C (B, D) | DNA gyrase subunit B,DNA gyrase subunit B | polymer | 202 | 22605.7 | 2 | UniProt (P66937) Pfam (PF01751) Pfam (PF00986) | Staphylococcus aureus | |
| 2 | B, D (A, C) | DNA gyrase subunit A | polymer | 490 | 55537.3 | 2 | UniProt (Q99XG5) Pfam (PF00521) | Staphylococcus aureus | |
| 3 | E, F (E, F) | DNA (5'-D(*GP*AP*GP*CP*GP*TP*AP*CP*AP*GP*CP*TP*GP*TP*AP*CP*GP*CP*TP*T)-3') | polymer | 20 | 6150.0 | 2 | synthetic construct | ||
| 4 | G, J (B, D) | MANGANESE (II) ION | non-polymer | 54.9 | 2 | Chemie (MN) | |||
| 5 | H (B) | SODIUM ION | non-polymer | 23.0 | 1 | Chemie (NA) | |||
| 6 | I (A) | GLYCEROL | non-polymer | 92.1 | 1 | Chemie (GOL) | |||
| 7 | K (C) | SULFATE ION | non-polymer | 96.1 | 1 | Chemie (SO4) | |||
| 8 | L (E) | (3~{R})-3-[[4-(3,4-dihydro-2~{H}-pyrano[2,3-c]pyridin-6-ylmethylamino)piperidin-1-yl]methyl]-1,4,7-triazatricyclo[6.3.1.0^{4,12}]dodeca-6,8(12),9-triene-5,11-dione | non-polymer | 448.5 | 1 | Chemie (JHN) | |||
| 9 | M, N, O, P, Q... (B, A, D, C, E...) | water | water | 18.0 | 602 | Chemie (HOH) |
Sequence modifications
B, D: 410 - 543 (UniProt: P66937)
B, D: 580 - 644 (UniProt: P66937)
| PDB | External Database | Details |
|---|---|---|
| Met 409 | - | initiating methionine |
| PDB | External Database | Details |
|---|---|---|
| Thr 578 | - | linker |
| Gly 579 | - | linker |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 6 |
| Total formula weight | 168586.0 | |
| Non-Polymers* | Number of molecules | 6 |
| Total formula weight | 769.5 | |
| All* | Total formula weight | 169355.5 |
