Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0003677 | molecular_function | DNA binding |
| A | 0003918 | molecular_function | DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity |
| A | 0005524 | molecular_function | ATP binding |
| A | 0006259 | biological_process | DNA metabolic process |
| A | 0006265 | biological_process | DNA topological change |
| B | 0003677 | molecular_function | DNA binding |
| B | 0003918 | molecular_function | DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity |
| B | 0005524 | molecular_function | ATP binding |
| B | 0006265 | biological_process | DNA topological change |
| C | 0003677 | molecular_function | DNA binding |
| C | 0003918 | molecular_function | DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity |
| C | 0005524 | molecular_function | ATP binding |
| C | 0006259 | biological_process | DNA metabolic process |
| C | 0006265 | biological_process | DNA topological change |
| D | 0003677 | molecular_function | DNA binding |
| D | 0003918 | molecular_function | DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity |
| D | 0005524 | molecular_function | ATP binding |
| D | 0006265 | biological_process | DNA topological change |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 9 |
| Details | binding site for residue MN B 701 |
| Chain | Residue |
| B | GLU435 |
| B | ASP508 |
| B | ASP510 |
| B | HOH806 |
| B | HOH810 |
| B | HOH825 |
| B | HOH831 |
| E | DA9 |
| E | HOH223 |
| site_id | AC2 |
| Number of Residues | 2 |
| Details | binding site for residue NA B 702 |
| Chain | Residue |
| B | GLU427 |
| B | GLU428 |
| site_id | AC3 |
| Number of Residues | 6 |
| Details | binding site for residue GOL A 501 |
| Chain | Residue |
| A | ASP96 |
| A | PHE97 |
| A | MET113 |
| A | PRO219 |
| A | THR220 |
| A | ARG485 |
| site_id | AC4 |
| Number of Residues | 7 |
| Details | binding site for residue MN D 701 |
| Chain | Residue |
| A | TYR123 |
| A | HOH609 |
| D | GLU435 |
| D | ASP508 |
| D | HOH807 |
| F | DC8 |
| F | DA9 |
| site_id | AC5 |
| Number of Residues | 4 |
| Details | binding site for residue SO4 C 501 |
| Chain | Residue |
| A | ARG429 |
| C | ARG429 |
| C | HOH739 |
| C | HOH800 |
| site_id | AC6 |
| Number of Residues | 14 |
| Details | binding site for residue JHN E 101 |
| Chain | Residue |
| A | ALA68 |
| A | MET75 |
| A | ASP83 |
| A | MET121 |
| A | HOH797 |
| C | ALA68 |
| C | MET75 |
| C | ASP83 |
| C | MET121 |
| E | DG10 |
| E | DC11 |
| E | HOH235 |
| F | DG10 |
| F | DC11 |
Functional Information from PROSITE/UniProt
| site_id | PS00177 |
| Number of Residues | 9 |
| Details | TOPOISOMERASE_II DNA topoisomerase II signature. LVEGDSAGG |
| Chain | Residue | Details |
| B | LEU433-GLY441 | |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 228 |
| Details | Domain: {"description":"Toprim","evidences":[{"source":"HAMAP-Rule","id":"MF_01898","evidenceCode":"ECO:0000255"}]} |
| site_id | SWS_FT_FI2 |
| Number of Residues | 6 |
| Details | Binding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_01898","evidenceCode":"ECO:0000255"}]} |
| site_id | SWS_FT_FI3 |
| Number of Residues | 4 |
| Details | Site: {"description":"Interaction with DNA","evidences":[{"source":"HAMAP-Rule","id":"MF_01898","evidenceCode":"ECO:0000255"}]} |
| site_id | SWS_FT_FI4 |
| Number of Residues | 2 |
| Details | Active site: {"description":"O-(5'-phospho-DNA)-tyrosine intermediate","evidences":[{"source":"HAMAP-Rule","id":"MF_01897","evidenceCode":"ECO:0000255"}]} |
