6QTK

2.31A structure of gepotidacin with S.aureus DNA gyrase and doubly nicked DNA

Summary for 6QTK

• Entry DOI: 10.2210/pdb6qtk/pdb
• Descriptor: DNA gyrase subunit B, DNA gyrase subunit A, DNA (5'-D(*AP*GP*CP*CP*GP*TP*AP*G*GP*GP*TP*AP*CP*CP*TP*AP*CP*GP*GP*CP*T)-3'), ... (8 entities in total)
• Functional Keywords: inhibitor, dna, complex, isomerase
• Biological source: Staphylococcus aureus (strain N315); More
• Total number of polymer chains: 6
• Total formula weight: 169842.07

Authors

Bax, B.D. (deposition date: 2019-02-25, release date: 2019-03-13, Last modification date: 2024-01-24)

• Primary citation: Gibson, E.G.,Bax, B.,Chan, P.F.,Osheroff, N.; Mechanistic and Structural Basis for the Actions of the Antibacterial Gepotidacin against Staphylococcus aureus Gyrase.; Acs Infect Dis., 5:570-581, 2019; PubMed: 30757898; DOI: 10.1021/acsinfecdis.8b00315

Experimental method

X-RAY DIFFRACTION (2.31 Å)