2.37A structure of gepotidacin with S.aureus DNA gyrase and uncleaved DNA

Summary for 6QTP

DescriptorDNA gyrase subunit B,DNA gyrase subunit B, DNA gyrase subunit A, DNA (5'-D(*GP*AP*GP*CP*GP*TP*AP*CP*AP*GP*CP*TP*GP*TP*AP*CP*GP*CP*TP*T)-3'), ... (9 entities in total)
Functional Keywordsinhibitor, dna, complex, isomerase
Biological sourceStaphylococcus aureus
Total number of polymer chains6
Total molecular weight169355.5
Bax, B.D. (deposition date: 2019-02-25, release date: 2019-03-13)
Primary citation
Gibson, E.G.,Bax, B.,Chan, P.F.,Osheroff, N.
Mechanistic and Structural Basis for the Actions of the Antibacterial Gepotidacin against Staphylococcus aureus Gyrase.
ACS Infect Dis, 2019
PubMed: 30757898 (PDB entries with the same primary citation)
DOI: 10.1021/acsinfecdis.8b00315
MImport into Mendeley
Experimental method

Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers 0.2276 0.4% 1.0% 0.5%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution

More Asymmetric unit images

Molmil generated image of 6qtp
no rotation
Molmil generated image of 6qtp
rotated about x axis by 90°
Molmil generated image of 6qtp
rotated about y axis by 90°