6QM7
Leishmania tarentolae proteasome 20S subunit complexed with GSK3494245
Summary for 6QM7
Entry DOI | 10.2210/pdb6qm7/pdb |
EMDB information | 4590 |
Descriptor | Proteasome alpha1 chain, Proteasome beta3 chain, Proteasome beta4 chain, ... (16 entities in total) |
Functional Keywords | proteasome 20s subunit, hydrolase |
Biological source | Leishmania tarentolae More |
Total number of polymer chains | 28 |
Total formula weight | 848665.39 |
Authors | Rowland, P.,Goswami, P. (deposition date: 2019-02-01, release date: 2019-04-17, Last modification date: 2024-05-15) |
Primary citation | Wyllie, S.,Brand, S.,Thomas, M.,De Rycker, M.,Chung, C.W.,Pena, I.,Bingham, R.P.,Bueren-Calabuig, J.A.,Cantizani, J.,Cebrian, D.,Craggs, P.D.,Ferguson, L.,Goswami, P.,Hobrath, J.,Howe, J.,Jeacock, L.,Ko, E.J.,Korczynska, J.,MacLean, L.,Manthri, S.,Martinez, M.S.,Mata-Cantero, L.,Moniz, S.,Nuhs, A.,Osuna-Cabello, M.,Pinto, E.,Riley, J.,Robinson, S.,Rowland, P.,Simeons, F.R.C.,Shishikura, Y.,Spinks, D.,Stojanovski, L.,Thomas, J.,Thompson, S.,Viayna Gaza, E.,Wall, R.J.,Zuccotto, F.,Horn, D.,Ferguson, M.A.J.,Fairlamb, A.H.,Fiandor, J.M.,Martin, J.,Gray, D.W.,Miles, T.J.,Gilbert, I.H.,Read, K.D.,Marco, M.,Wyatt, P.G. Preclinical candidate for the treatment of visceral leishmaniasis that acts through proteasome inhibition. Proc.Natl.Acad.Sci.USA, 116:9318-9323, 2019 Cited by PubMed: 30962368DOI: 10.1073/pnas.1820175116 PDB entries with the same primary citation |
Experimental method | ELECTRON MICROSCOPY (2.8 Å) |
Structure validation
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