6QM7

Leishmania tarentolae proteasome 20S subunit complexed with GSK3494245

Summary for 6QM7

EMDB information4590
DescriptorProteasome alpha1 chain, Proteasome alpha2 chain, Proteasome alpha3 chain, ... (16 entities in total)
Functional Keywordsproteasome 20s subunit, hydrolase
Biological sourceLeishmania tarentolae
Total number of polymer chains28
Total molecular weight848665.39
Authors
Rowland, P.,Goswami, P. (deposition date: 2019-02-01, release date: 2019-04-17, Last modification date: 2019-12-18)
Primary citation
Wyllie, S.,Brand, S.,Thomas, M.,De Rycker, M.,Chung, C.W.,Pena, I.,Bingham, R.P.,Bueren-Calabuig, J.A.,Cantizani, J.,Cebrian, D.,Craggs, P.D.,Ferguson, L.,Goswami, P.,Hobrath, J.,Howe, J.,Jeacock, L.,Ko, E.J.,Korczynska, J.,MacLean, L.,Manthri, S.,Martinez, M.S.,Mata-Cantero, L.,Moniz, S.,Nuhs, A.,Osuna-Cabello, M.,Pinto, E.,Riley, J.,Robinson, S.,Rowland, P.,Simeons, F.R.C.,Shishikura, Y.,Spinks, D.,Stojanovski, L.,Thomas, J.,Thompson, S.,Viayna Gaza, E.,Wall, R.J.,Zuccotto, F.,Horn, D.,Ferguson, M.A.J.,Fairlamb, A.H.,Fiandor, J.M.,Martin, J.,Gray, D.W.,Miles, T.J.,Gilbert, I.H.,Read, K.D.,Marco, M.,Wyatt, P.G.
Preclinical candidate for the treatment of visceral leishmaniasis that acts through proteasome inhibition.
Proc.Natl.Acad.Sci.USA, 116:9318-9323, 2019
PubMed: 30962368 (PDB entries with the same primary citation)
DOI: 10.1073/pnas.1820175116
MImport into Mendeley
Experimental method
ELECTRON MICROSCOPY (2.8 Å)
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Structure validation

ClashscoreRamachandran outliersSidechain outliers5 0.3% 9.5%MetricValuePercentile RanksWorseBetterPercentile relative to all structuresPercentile relative to all EM structures
Download full validation reportDownload
171588
PDB entries from 2020-11-25