6QM7

Leishmania tarentolae proteasome 20S subunit complexed with GSK3494245

Functional Information from GO Data

Chain	GOid	namespace	contents
a	0005634	cellular_component	nucleus
a	0005737	cellular_component	cytoplasm
a	0005839	cellular_component	proteasome core complex
a	0030163	biological_process	protein catabolic process
A	0005634	cellular_component	nucleus
A	0005737	cellular_component	cytoplasm
A	0005839	cellular_component	proteasome core complex
A	0006511	biological_process	ubiquitin-dependent protein catabolic process
A	0019773	cellular_component	proteasome core complex, alpha-subunit complex
A	0030163	biological_process	protein catabolic process
b	0005634	cellular_component	nucleus
b	0005737	cellular_component	cytoplasm
b	0005839	cellular_component	proteasome core complex
b	0019774	cellular_component	proteasome core complex, beta-subunit complex
b	0030163	biological_process	protein catabolic process
B	0005634	cellular_component	nucleus
B	0005737	cellular_component	cytoplasm
B	0005839	cellular_component	proteasome core complex
B	0006511	biological_process	ubiquitin-dependent protein catabolic process
B	0019773	cellular_component	proteasome core complex, alpha-subunit complex
B	0030163	biological_process	protein catabolic process
C	0005634	cellular_component	nucleus
C	0005737	cellular_component	cytoplasm
C	0005839	cellular_component	proteasome core complex
C	0006511	biological_process	ubiquitin-dependent protein catabolic process
C	0019773	cellular_component	proteasome core complex, alpha-subunit complex
C	0030163	biological_process	protein catabolic process
D	0005634	cellular_component	nucleus
D	0005737	cellular_component	cytoplasm
D	0005839	cellular_component	proteasome core complex
D	0006511	biological_process	ubiquitin-dependent protein catabolic process
D	0019773	cellular_component	proteasome core complex, alpha-subunit complex
D	0030163	biological_process	protein catabolic process
E	0005634	cellular_component	nucleus
E	0005737	cellular_component	cytoplasm
E	0005839	cellular_component	proteasome core complex
E	0006511	biological_process	ubiquitin-dependent protein catabolic process
E	0019773	cellular_component	proteasome core complex, alpha-subunit complex
E	0030163	biological_process	protein catabolic process
E	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
F	0005634	cellular_component	nucleus
F	0005737	cellular_component	cytoplasm
F	0005839	cellular_component	proteasome core complex
F	0006511	biological_process	ubiquitin-dependent protein catabolic process
F	0019773	cellular_component	proteasome core complex, alpha-subunit complex
F	0030163	biological_process	protein catabolic process
G	0005634	cellular_component	nucleus
G	0005737	cellular_component	cytoplasm
G	0005839	cellular_component	proteasome core complex
G	0006511	biological_process	ubiquitin-dependent protein catabolic process
G	0019773	cellular_component	proteasome core complex, alpha-subunit complex
G	0030163	biological_process	protein catabolic process
H	0004298	molecular_function	threonine-type endopeptidase activity
H	0005634	cellular_component	nucleus
H	0005737	cellular_component	cytoplasm
H	0005839	cellular_component	proteasome core complex
H	0030163	biological_process	protein catabolic process
I	0004298	molecular_function	threonine-type endopeptidase activity
I	0005634	cellular_component	nucleus
I	0005737	cellular_component	cytoplasm
I	0005839	cellular_component	proteasome core complex
I	0030163	biological_process	protein catabolic process
J	0005634	cellular_component	nucleus
J	0005737	cellular_component	cytoplasm
J	0005839	cellular_component	proteasome core complex
J	0019774	cellular_component	proteasome core complex, beta-subunit complex
J	0030163	biological_process	protein catabolic process
J	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
K	0005634	cellular_component	nucleus
K	0005737	cellular_component	cytoplasm
K	0005839	cellular_component	proteasome core complex
K	0010498	biological_process	proteasomal protein catabolic process
K	0030163	biological_process	protein catabolic process
L	0000502	cellular_component	proteasome complex
L	0004298	molecular_function	threonine-type endopeptidase activity
L	0005634	cellular_component	nucleus
L	0005737	cellular_component	cytoplasm
L	0005839	cellular_component	proteasome core complex
L	0030163	biological_process	protein catabolic process
M	0005634	cellular_component	nucleus
M	0005737	cellular_component	cytoplasm
M	0005839	cellular_component	proteasome core complex
M	0030163	biological_process	protein catabolic process
N	0005634	cellular_component	nucleus
N	0005737	cellular_component	cytoplasm
N	0005839	cellular_component	proteasome core complex
N	0019774	cellular_component	proteasome core complex, beta-subunit complex
N	0030163	biological_process	protein catabolic process
O	0005634	cellular_component	nucleus
O	0005737	cellular_component	cytoplasm
O	0005839	cellular_component	proteasome core complex
O	0006511	biological_process	ubiquitin-dependent protein catabolic process
O	0019773	cellular_component	proteasome core complex, alpha-subunit complex
O	0030163	biological_process	protein catabolic process
P	0005634	cellular_component	nucleus
P	0005737	cellular_component	cytoplasm
P	0005839	cellular_component	proteasome core complex
P	0006511	biological_process	ubiquitin-dependent protein catabolic process
P	0019773	cellular_component	proteasome core complex, alpha-subunit complex
P	0030163	biological_process	protein catabolic process
Q	0005634	cellular_component	nucleus
Q	0005737	cellular_component	cytoplasm
Q	0005839	cellular_component	proteasome core complex
Q	0006511	biological_process	ubiquitin-dependent protein catabolic process
Q	0019773	cellular_component	proteasome core complex, alpha-subunit complex
Q	0030163	biological_process	protein catabolic process
R	0005634	cellular_component	nucleus
R	0005737	cellular_component	cytoplasm
R	0005839	cellular_component	proteasome core complex
R	0006511	biological_process	ubiquitin-dependent protein catabolic process
R	0019773	cellular_component	proteasome core complex, alpha-subunit complex
R	0030163	biological_process	protein catabolic process
S	0005634	cellular_component	nucleus
S	0005737	cellular_component	cytoplasm
S	0005839	cellular_component	proteasome core complex
S	0006511	biological_process	ubiquitin-dependent protein catabolic process
S	0019773	cellular_component	proteasome core complex, alpha-subunit complex
S	0030163	biological_process	protein catabolic process
S	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
T	0005634	cellular_component	nucleus
T	0005737	cellular_component	cytoplasm
T	0005839	cellular_component	proteasome core complex
T	0006511	biological_process	ubiquitin-dependent protein catabolic process
T	0019773	cellular_component	proteasome core complex, alpha-subunit complex
T	0030163	biological_process	protein catabolic process
U	0005634	cellular_component	nucleus
U	0005737	cellular_component	cytoplasm
U	0005839	cellular_component	proteasome core complex
U	0006511	biological_process	ubiquitin-dependent protein catabolic process
U	0019773	cellular_component	proteasome core complex, alpha-subunit complex
U	0030163	biological_process	protein catabolic process
V	0004298	molecular_function	threonine-type endopeptidase activity
V	0005634	cellular_component	nucleus
V	0005737	cellular_component	cytoplasm
V	0005839	cellular_component	proteasome core complex
V	0030163	biological_process	protein catabolic process
W	0004298	molecular_function	threonine-type endopeptidase activity
W	0005634	cellular_component	nucleus
W	0005737	cellular_component	cytoplasm
W	0005839	cellular_component	proteasome core complex
W	0030163	biological_process	protein catabolic process
X	0005634	cellular_component	nucleus
X	0005737	cellular_component	cytoplasm
X	0005839	cellular_component	proteasome core complex
X	0019774	cellular_component	proteasome core complex, beta-subunit complex
X	0030163	biological_process	protein catabolic process
X	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
Y	0005634	cellular_component	nucleus
Y	0005737	cellular_component	cytoplasm
Y	0005839	cellular_component	proteasome core complex
Y	0010498	biological_process	proteasomal protein catabolic process
Y	0030163	biological_process	protein catabolic process
Z	0000502	cellular_component	proteasome complex
Z	0004298	molecular_function	threonine-type endopeptidase activity
Z	0005634	cellular_component	nucleus
Z	0005737	cellular_component	cytoplasm
Z	0005839	cellular_component	proteasome core complex
Z	0030163	biological_process	protein catabolic process

Functional Information from PDB Data

site_id	AC1
Number of Residues	17
Details	binding site for residue J6E L 4000

Chain	Residue
K	PHE24
L	ASP214
L	ASP215
L	SER226
L	VAL227
L	GLY228
L	SER229
L	SER231
X	LEU32
L	THR100
L	SER120
L	GLY122
L	GLY146
L	SER195
L	MET196
L	GLY197
L	TYR212

---

site_id	AC2
Number of Residues	18
Details	binding site for residue J6E Z 4000

Chain	Residue
J	LEU32
Y	PHE24
Z	THR100
Z	SER120
Z	GLY122
Z	GLY146
Z	SER195
Z	MET196
Z	GLY197
Z	TYR212
Z	ASP214
Z	ASP215
Z	SER226
Z	VAL227
Z	GLY228
Z	SER229
Z	SER231
Z	HOH4116

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Functional Information from PROSITE/UniProt

site_id	PS00300
Number of Residues	14
Details	SRP54 SRP54-type proteins GTP-binding domain signature. PImFTSKSEyDrgV

Chain	Residue	Details
E	PRO99-VAL112

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site_id	PS00388
Number of Residues	23
Details	PROTEASOME_ALPHA_1 Proteasome alpha-type subunits signature. YdrgvNtFSPeGRifQIEYAveA

Chain	Residue	Details
E	TYR108-ALA130
B	ALA4-ALA26
A	PHE6-ALA28
C	TYR5-ALA27
F	TYR170-ALA192
D	TYR3-ALA25

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site_id	PS00854
Number of Residues	48
Details	PROTEASOME_BETA_1 Proteasome beta-type subunits signature. LAVsYngGVVLAADsrtssgtyvvnrasn.KltkltkkiyccrsGsaAD

Chain	Residue	Details
H	LEU58-ASP105
a	ALA137-ASP185
I	VAL33-ASP80
L	LEU103-ASP150
J	MET12-ASP59
b	ILE8-ASP55

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