6QKK

Aplysia californica AChBP in complex with 2-Fluoro-(carbamoylpyridinyl)deschloroepibatidine analogue (1)

Summary for 6QKK

• Entry DOI: 10.2210/pdb6qkk/pdb
• Descriptor: Soluble acetylcholine receptor, 4-[5-[(1~{R},2~{R},4~{S})-7-azabicyclo[2.2.1]heptan-2-yl]-2-fluoranyl-pyridin-3-yl]benzamide, PHOSPHATE ION, ... (7 entities in total)
• Functional Keywords: achbp, acetylcholine, signaling protein
• Biological source: Aplysia californica (California sea hare)
• Total number of polymer chains: 10
• Total formula weight: 290786.31

Authors

Davis, S.,Bueno, R.V.,Dawson, A.,Hunter, W.N. (deposition date: 2019-01-29, release date: 2020-02-19, Last modification date: 2024-01-24)

• Primary citation: Bueno, R.V.,Davis, S.,Dawson, A.,Ondachi, P.W.,Carroll, F.I.,Hunter, W.N.; Interactions between 2'-fluoro-(carbamoylpyridinyl)deschloroepibatidine analogues and acetylcholine-binding protein inform on potent antagonist activity against nicotinic receptors; Acta Crystallogr.,Sect.D, 78:-, 2022; DOI: 10.1107/S2059798322000754

Experimental method

X-RAY DIFFRACTION (2.2 Å)