6QEX
Nanodisc reconstituted human ABCB1 in complex with UIC2 fab and taxol
Summary for 6QEX
Entry DOI | 10.2210/pdb6qex/pdb |
Related | 6QEE |
EMDB information | 4536 4539 |
Descriptor | Multidrug resistance protein 1, UIC2 Fab lightchain, UIC2 Fab heavy chain, ... (7 entities in total) |
Functional Keywords | abcb1, p-glycoprotein, p-gp, multidrug exporter, abc transporter, membrane protein |
Biological source | Homo sapiens (Human) More |
Total number of polymer chains | 3 |
Total formula weight | 199531.22 |
Authors | Alam, A.,Locher, K.P. (deposition date: 2019-01-08, release date: 2019-02-27, Last modification date: 2021-06-02) |
Primary citation | Alam, A.,Kowal, J.,Broude, E.,Roninson, I.,Locher, K.P. Structural insight into substrate and inhibitor discrimination by human P-glycoprotein. Science, 363:753-756, 2019 Cited by PubMed: 30765569DOI: 10.1126/science.aav7102 PDB entries with the same primary citation |
Experimental method | ELECTRON MICROSCOPY (3.6 Å) |
Structure validation
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