6QDX

Structure of E.coli RlmJ in complex with a bisubstrate analogue (BA4)

6QDX の概要

• エントリーDOI: 10.2210/pdb6qdx/pdb
• 分子名称: Ribosomal RNA large subunit methyltransferase J, (2~{S})-4-[[(2~{S},3~{S},4~{R},5~{R})-5-(6-aminopurin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methyl-[3-[[9-[(2~{S},3~{R},4~{S},5~{S})-5-(hydroxymethyl)-3,4-bis(oxidanyl)oxolan-2-yl]purin-6-yl]amino]propyl]amino]-2-azanyl-butanoic acid (3 entities in total)
• 機能のキーワード: rna mtases, methyltransferase, m6a, transition state analogue, inhibitor, rna binding, trmk, rlmj, m1a, structure., transferase
• 由来する生物種: Escherichia coli
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 131786.48

構造登録者

Oerum, S.,Catala, M.,Atdjian, C.,Brachet, F.,Ponchon, L.,Barraud, P.,Iannazzo, L.,Droogmans, L.,Braud, E.,Etheve-Quelquejeu, M.,Tisne, C. (登録日: 2019-01-03, 公開日: 2019-03-27, 最終更新日: 2024-01-24)

• 主引用文献: Oerum, S.,Catala, M.,Atdjian, C.,Brachet, F.,Ponchon, L.,Barraud, P.,Iannazzo, L.,Droogmans, L.,Braud, E.,Etheve-Quelquejeu, M.,Tisne, C.; Bisubstrate analogues as structural tools to investigate m6A methyltransferase active sites.; Rna Biol., 16:798-808, 2019; PubMed: 30879411; DOI: 10.1080/15476286.2019.1589360

実験手法

X-RAY DIFFRACTION (2.1 Å)