6QBF

Crystal structure of the pathological D187N variant of calcium-free human gelsolin.

Summary for 6QBF

• Entry DOI: 10.2210/pdb6qbf/pdb
• Related: 3FFN 6Q9R 6Q9Z
• Descriptor: Gelsolin, SULFATE ION, GLYCEROL, ... (5 entities in total)
• Functional Keywords: amyloidosis, gelsolin, actin-binding, pathological mutation, structural protein
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 2
• Total formula weight: 171340.62

Authors

Scalone, E.,Boni, F.,Milani, M.,Eloise, M.,de Rosa, M. (deposition date: 2018-12-21, release date: 2019-11-27, Last modification date: 2024-01-24)

• Primary citation: de Rosa, M.,Barbiroli, A.,Boni, F.,Scalone, E.,Mattioni, D.,Vanoni, M.A.,Patrone, M.,Bollati, M.,Mastrangelo, E.,Giorgino, T.,Milani, M.; The structure of N184K amyloidogenic variant of gelsolin highlights the role of the H-bond network for protein stability and aggregation properties.; Eur.Biophys.J., 49:11-19, 2020; PubMed: 31724080; DOI: 10.1007/s00249-019-01409-9

Experimental method

X-RAY DIFFRACTION (3.499 Å)