6Q9R
Crystal structure of the pathological N184K variant of calcium-free human gelsolin
Summary for 6Q9R
Entry DOI | 10.2210/pdb6q9r/pdb |
Related | 3FFN |
Descriptor | Gelsolin, CHLORIDE ION, GLYCEROL, ... (6 entities in total) |
Functional Keywords | amyloidosis, gelsolin, actin-binding, pathological mutation, structural protein |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 2 |
Total formula weight | 173264.48 |
Authors | Scalone, E.,Boni, F.,Milani, M.,Eloise, M.,de Rosa, M. (deposition date: 2018-12-18, release date: 2019-11-27, Last modification date: 2024-01-24) |
Primary citation | de Rosa, M.,Barbiroli, A.,Boni, F.,Scalone, E.,Mattioni, D.,Vanoni, M.A.,Patrone, M.,Bollati, M.,Mastrangelo, E.,Giorgino, T.,Milani, M. The structure of N184K amyloidogenic variant of gelsolin highlights the role of the H-bond network for protein stability and aggregation properties. Eur.Biophys.J., 49:11-19, 2020 Cited by PubMed: 31724080DOI: 10.1007/s00249-019-01409-9 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.73 Å) |
Structure validation
Download full validation report