6QBA

Crystal Structure of Retinol-Binding Protein 4 (RBP4) in complex with non-retinoid ligand A1120 and engineered binding scaffold

6QBA の概要

• エントリーDOI: 10.2210/pdb6qba/pdb
• 分子名称: Retinol-binding protein 4, DNA-binding protein 7a, 2-[({4-[2-(trifluoromethyl)phenyl]piperidin-1-yl}carbonyl)amino]benzoic acid, ... (8 entities in total)
• 機能のキーワード: lipocalin, rbp4, retinol binding protein, transport protein
• 由来する生物種: Homo sapiens (Human); 詳細
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 29281.70

構造登録者

Mlynek, G.,Brey, C.U.,Djinovic-Carugo, K.,Puehringer, D. (登録日: 2018-12-20, 公開日: 2020-06-03, 最終更新日: 2024-01-24)

• 主引用文献: Zajc, C.U.,Dobersberger, M.,Schaffner, I.,Mlynek, G.,Puhringer, D.,Salzer, B.,Djinovic-Carugo, K.,Steinberger, P.,De Sousa Linhares, A.,Yang, N.J.,Obinger, C.,Holter, W.,Traxlmayr, M.W.,Lehner, M.; A conformation-specific ON-switch for controlling CAR T cells with an orally available drug.; Proc.Natl.Acad.Sci.USA, 117:14926-14935, 2020; PubMed: 32554495; DOI: 10.1073/pnas.1911154117

実験手法

X-RAY DIFFRACTION (1.8 Å)