6Q5F

OXA-48_P68A-CAZ. Evolutionary trade-offs of OXA-48 mediated ceftazidime-avibactam resistance

Summary for 6Q5F

• Entry DOI: 10.2210/pdb6q5f/pdb
• Descriptor: Beta-lactamase, 1-({(2R)-2-[(1R)-1-{[(2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-{[(2-carboxypropan-2-yl)oxy]imino}acetyl]amino}-2-oxoethyl]-4-carboxy-3,6-dihydro-2H-1,3-thiazin-5-yl}methyl)pyridinium, CHLORIDE ION, ... (8 entities in total)
• Functional Keywords: oxa-48, ceftazidime, avibactam, resistance development, evolution, escherichia coli, klebsiella pneumoniae, carbapenemase, carbapenem, antibiotic
• Biological source: Klebsiella pneumoniae; More
• Total number of polymer chains: 4
• Total formula weight: 123533.36

Authors

Frohlich, C.,Sorum, V.,Thomassen, A.M.,Johnsen, P.J.,Leiros, H.-K.S.,Samuelsen, O. (deposition date: 2018-12-08, release date: 2019-03-20, Last modification date: 2024-01-24)

• Primary citation: Frohlich, C.,Sorum, V.,Thomassen, A.M.,Johnsen, P.J.,Leiros, H.S.,Samuelsen, O.; OXA-48-Mediated Ceftazidime-Avibactam Resistance Is Associated with Evolutionary Trade-Offs.; Msphere, 4:-, 2019; PubMed: 30918055; DOI: 10.1128/mSphere.00024-19

Experimental method

X-RAY DIFFRACTION (2.5 Å)