6Q5F

OXA-48_P68A-CAZ. Evolutionary trade-offs of OXA-48 mediated ceftazidime-avibactam resistance

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0008658	molecular_function	penicillin binding
A	0008800	molecular_function	beta-lactamase activity
A	0017001	biological_process	antibiotic catabolic process
B	0008658	molecular_function	penicillin binding
B	0008800	molecular_function	beta-lactamase activity
B	0017001	biological_process	antibiotic catabolic process
C	0008658	molecular_function	penicillin binding
C	0008800	molecular_function	beta-lactamase activity
C	0017001	biological_process	antibiotic catabolic process
D	0008658	molecular_function	penicillin binding
D	0008800	molecular_function	beta-lactamase activity
D	0017001	biological_process	antibiotic catabolic process

Functional Information from PDB Data

site_id	AC1
Number of Residues	13
Details	binding site for residue CTJ A 301

Chain	Residue
A	ALA69
A	THR213
A	ARG214
A	ARG250
A	HOH435
A	SER70
A	ILE102
A	TRP105
A	VAL120
A	THR209
A	GLY210
A	TYR211
A	SER212

---

site_id	AC2
Number of Residues	2
Details	binding site for residue CL A 302

Chain	Residue
A	ARG206
B	ARG206

---

site_id	AC3
Number of Residues	6
Details	binding site for residue CL A 303

Chain	Residue
A	ASP88
A	GLU89
A	GLN91
A	PHE93
A	ASN110
A	LEU111

---

site_id	AC4
Number of Residues	5
Details	binding site for residue PGE A 304

Chain	Residue
A	GLU132
A	HOH402
A	HOH407
A	HOH462
A	HOH466

---

site_id	AC5
Number of Residues	4
Details	binding site for residue CL B 301

Chain	Residue
B	PHE72
B	KCX73
B	ASN76
B	TRP157

---

site_id	AC6
Number of Residues	3
Details	binding site for residue CL B 302

Chain	Residue
B	SER184
B	ARG186
B	SER187

---

site_id	AC7
Number of Residues	5
Details	binding site for residue PGE B 303

Chain	Residue
B	ASN179
B	LEU181
B	VAL183
B	GLU185
B	GLN188

---

site_id	AC8
Number of Residues	2
Details	binding site for residue CL C 302

Chain	Residue
C	ARG206
D	ARG206

---

site_id	AC9
Number of Residues	4
Details	binding site for residue PGE C 303

Chain	Residue
A	ARG128
C	HOH405
C	HOH416
C	HOH432

---

site_id	AD1
Number of Residues	2
Details	binding site for residue PEG C 304

Chain	Residue
C	ARG214
C	CTJ301

---

site_id	AD2
Number of Residues	5
Details	binding site for residue CL D 301

Chain	Residue
D	PHE72
D	KCX73
D	ASN76
D	TYR123
D	TRP157

---

site_id	AD3
Number of Residues	16
Details	binding site for Di-peptide CTJ C 301 and SER C 70

Chain	Residue
C	ALA68
C	ALA69
C	THR71
C	PHE72
C	LYS73
C	TRP105
C	SER118
C	VAL120
C	THR209
C	GLY210
C	TYR211
C	SER212
C	THR213
C	ARG214
C	ARG250
C	PEG304

---

site_id	AD4
Number of Residues	12
Details	binding site for Di-peptide SO4 D 302 and ARG D 250

Chain	Residue
D	SER118
D	THR209
D	GLY210
D	TYR211
D	TRP221
D	MET237
D	LEU247
D	GLY248
D	LEU249
D	GLN251
D	ALA252
D	THR254

---

Functional Information from PROSITE/UniProt

site_id	PS00337
Number of Residues	11
Details	BETA_LACTAMASE_D Beta-lactamase class-D active site. AaSTFKIPnSL

Chain	Residue	Details
B	ALA68-LEU78
A	ALA68-LEU78

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	4
Details	Active site: {"description":"Acyl-ester intermediate","evidences":[{"source":"PIRSR","id":"PIRSR602137-50","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"25406838","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"26731698","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"31358584","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"32150407","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4WMC","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5FAQ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5FAS","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6P97","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6P98","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6P99","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6P9C","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6V1O","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	12
Details	Binding site: {"evidences":[{"source":"UniProtKB","id":"Q8RLA6","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"UniProtKB","id":"P13661","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	4
Details	Modified residue: {"description":"N6-carboxylysine","evidences":[{"source":"PIRSR","id":"PIRSR602137-50","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"19477418","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"25406838","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3HBR","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4WMC","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---