6Q5F
OXA-48_P68A-CAZ. Evolutionary trade-offs of OXA-48 mediated ceftazidime-avibactam resistance
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, C (A, C) | Beta-lactamase | polymer | 265 | 30370.7 | 2 | UniProt (Q6XEC0) | Klebsiella pneumoniae | |
| 2 | B, D (B, D) | Beta-lactamase | polymer | 265 | 30413.7 | 2 | UniProt (Q6XEC0) | Klebsiella pneumoniae | |
| 3 | E, L (A, C) | 1-({(2R)-2-[(1R)-1-{[(2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-{[(2-carboxypropan-2-yl)oxy]imino}acetyl]amino}-2-oxoethyl]-4-carboxy-3,6-dihydro-2H-1,3-thiazin-5-yl}methyl)pyridinium | non-polymer | 549.6 | 2 | Chemie (CTJ) | |||
| 4 | F, G, I, J, M... (A, B, C, D) | CHLORIDE ION | non-polymer | 35.5 | 6 | Chemie (CL) | |||
| 5 | H, K, N (A, B, C) | TRIETHYLENE GLYCOL | non-polymer | 150.2 | 3 | Chemie (PGE) | |||
| 6 | O (C) | DI(HYDROXYETHYL)ETHER | non-polymer | 106.1 | 1 | Chemie (PEG) | |||
| 7 | Q (D) | SULFATE ION | non-polymer | 96.1 | 1 | Chemie (SO4) | |||
| 8 | R, S, T, U (A, B, C, D) | water | water | 18.0 | 422 | Chemie (HOH) |
Sequence modifications
A, C: 1 - 265 (UniProt: Q6XEC0)
B, D: 1 - 265 (UniProt: Q6XEC0)
| PDB | External Database | Details |
|---|---|---|
| Ala 68 | Pro 68 | engineered mutation |
| PDB | External Database | Details |
|---|---|---|
| Ala 68 | Pro 68 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 121568.7 | |
| Non-Polymers* | Number of molecules | 13 |
| Total formula weight | 1964.6 | |
| All* | Total formula weight | 123533.4 |
