6Q5F
OXA-48_P68A-CAZ. Evolutionary trade-offs of OXA-48 mediated ceftazidime-avibactam resistance
Summary for 6Q5F
Entry DOI | 10.2210/pdb6q5f/pdb |
Descriptor | Beta-lactamase, 1-({(2R)-2-[(1R)-1-{[(2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-{[(2-carboxypropan-2-yl)oxy]imino}acetyl]amino}-2-oxoethyl]-4-carboxy-3,6-dihydro-2H-1,3-thiazin-5-yl}methyl)pyridinium, CHLORIDE ION, ... (8 entities in total) |
Functional Keywords | oxa-48, ceftazidime, avibactam, resistance development, evolution, escherichia coli, klebsiella pneumoniae, carbapenemase, carbapenem, antibiotic |
Biological source | Klebsiella pneumoniae More |
Total number of polymer chains | 4 |
Total formula weight | 123533.36 |
Authors | Frohlich, C.,Sorum, V.,Thomassen, A.M.,Johnsen, P.J.,Leiros, H.-K.S.,Samuelsen, O. (deposition date: 2018-12-08, release date: 2019-03-20, Last modification date: 2024-01-24) |
Primary citation | Frohlich, C.,Sorum, V.,Thomassen, A.M.,Johnsen, P.J.,Leiros, H.S.,Samuelsen, O. OXA-48-Mediated Ceftazidime-Avibactam Resistance Is Associated with Evolutionary Trade-Offs. Msphere, 4:-, 2019 Cited by PubMed: 30918055DOI: 10.1128/mSphere.00024-19 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.5 Å) |
Structure validation
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