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6Q2J

Cryo-EM structure of extracellular dimeric complex of RET/GFRAL/GDF15

Summary for 6Q2J
Entry DOI10.2210/pdb6q2j/pdb
EMDB information20572
DescriptorGrowth/differentiation factor 15, GDNF family receptor alpha-like, Proto-oncogene tyrosine-protein kinase receptor Ret, ... (5 entities in total)
Functional Keywordsret, receptor tyrosine kinase, cryo-em, signaling protein
Biological sourceHomo sapiens (Human)
More
Total number of polymer chains6
Total formula weight249618.58
Authors
Li, J.,Shang, G.J.,Chen, Y.J.,Brautigam, C.A.,Liou, J.,Zhang, X.W.,Bai, X.C. (deposition date: 2019-08-08, release date: 2019-10-02, Last modification date: 2020-07-29)
Primary citationLi, J.,Shang, G.,Chen, Y.J.,Brautigam, C.A.,Liou, J.,Zhang, X.,Bai, X.C.
Cryo-EM analyses reveal the common mechanism and diversification in the activation of RET by different ligands.
Elife, 8:-, 2019
Cited by
PubMed: 31535977
DOI: 10.7554/eLife.47650
PDB entries with the same primary citation
Experimental method
ELECTRON MICROSCOPY (4.1 Å)
Structure validation

217705

數據於2024-03-27公開中

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