6Q2J
Cryo-EM structure of extracellular dimeric complex of RET/GFRAL/GDF15
Summary for 6Q2J
Entry DOI | 10.2210/pdb6q2j/pdb |
EMDB information | 20572 |
Descriptor | Growth/differentiation factor 15, GDNF family receptor alpha-like, Proto-oncogene tyrosine-protein kinase receptor Ret, ... (5 entities in total) |
Functional Keywords | ret, receptor tyrosine kinase, cryo-em, signaling protein |
Biological source | Homo sapiens (Human) More |
Total number of polymer chains | 6 |
Total formula weight | 249618.58 |
Authors | Li, J.,Shang, G.J.,Chen, Y.J.,Brautigam, C.A.,Liou, J.,Zhang, X.W.,Bai, X.C. (deposition date: 2019-08-08, release date: 2019-10-02, Last modification date: 2020-07-29) |
Primary citation | Li, J.,Shang, G.,Chen, Y.J.,Brautigam, C.A.,Liou, J.,Zhang, X.,Bai, X.C. Cryo-EM analyses reveal the common mechanism and diversification in the activation of RET by different ligands. Elife, 8:-, 2019 Cited by PubMed: 31535977DOI: 10.7554/eLife.47650 PDB entries with the same primary citation |
Experimental method | ELECTRON MICROSCOPY (4.1 Å) |
Structure validation
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