6Q1P

Glucocerebrosidase in complex with pharmacological chaperone norIMX8

Summary for 6Q1P

• Entry DOI: 10.2210/pdb6q1p/pdb
• Descriptor: Glucosylceramidase, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, alpha-L-fucopyranose-(1-6)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (8 entities in total)
• Functional Keywords: pharmacological chaperone, gaucher disease, glycosidase, inhibitor, pka, hydrolase, hydrolase-inhibitor complex, hydrolase/inhibitor
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 2
• Total formula weight: 116059.79

Authors

Vickers, C.,Withers, S.G.,Boraston, A.B. (deposition date: 2019-08-05, release date: 2020-08-19)

• Primary citation: Santana, A.G.,Robinson, K.,Vickers, C.,Chen, H.,Zhou, S.,Boraston, A.B.,Clarke, L.A.,Withers, S.G.; Pharmacological chaperones for GCase that switch conformation with pH enhance enzyme levels in Gaucher animal models.; To Be Published,

Experimental method

X-RAY DIFFRACTION (2.796 Å)