6Q02
Polymerase Eta-catalyzed insertion of the mismatched A opposite template cytarabine (AraC) residue
Summary for 6Q02
Entry DOI | 10.2210/pdb6q02/pdb |
Related | 6PZ3 |
Descriptor | DNA polymerase eta, DNA Primer Strand, DNA template containing a cytarabin (AraC) residue, ... (7 entities in total) |
Functional Keywords | lesion bypass, dna damage, dna replication, chemotherapy, transferase, transferase-dna complex, transferase/dna |
Biological source | Homo sapiens (Human) More |
Total number of polymer chains | 3 |
Total formula weight | 55449.75 |
Authors | Rechkoblit, O.,Aggarwal, A.K. (deposition date: 2019-08-01, release date: 2019-11-20, Last modification date: 2023-10-11) |
Primary citation | Rechkoblit, O.,Johnson, R.E.,Buku, A.,Prakash, L.,Prakash, S.,Aggarwal, A.K. Structural insights into mutagenicity of anticancer nucleoside analog cytarabine during replication by DNA polymerase eta. Sci Rep, 9:16400-16400, 2019 Cited by PubMed: 31704958DOI: 10.1038/s41598-019-52703-7 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.09 Å) |
Structure validation
Download full validation report