6PZS

Crystal structure of Danio rerio histone deacetylase 6 catalytic domain 2 complexed with JR005

Summary for 6PZS

Entry DOI	10.2210/pdb6pzs/pdb
Descriptor	Hdac6 protein, ZINC ION, POTASSIUM ION, ... (7 entities in total)
Functional Keywords	histone deacetylase, metallohydrolase, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
Biological source	Danio rerio (Zebrafish)
Total number of polymer chains	1
Total formula weight	40330.45
Authors	Osko, J.D.,Christianson, D.W. (deposition date: 2019-08-01, release date: 2020-02-05, Last modification date: 2023-10-11)
Primary citation	Osko, J.D.,Porter, N.J.,Narayana Reddy, P.A.,Xiao, Y.C.,Rokka, J.,Jung, M.,Hooker, J.M.,Salvino, J.M.,Christianson, D.W. Exploring Structural Determinants of Inhibitor Affinity and Selectivity in Complexes with Histone Deacetylase 6. J.Med.Chem., 63:295-308, 2020 Cited by PubMed: 31793776 DOI: 10.1021/acs.jmedchem.9b01540 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.79 Å)

Structure validation