6PV9

Human PD-L1 bound to a macrocyclic peptide which blocks the PD-1/PD-L1 interaction

Summary for 6PV9

Entry DOI	10.2210/pdb6pv9/pdb
Descriptor	Programmed cell death 1 ligand 1, macrocyclic peptide (3 entities in total)
Functional Keywords	pd-l1 pd-1 cancer immunotherapy checkpoint inhibitor, immune system
Biological source	Homo sapiens (Human) More
Total number of polymer chains	2
Total formula weight	27296.09
Authors	Appleby, T.C.,Lad, L.,Gross, M.L. (deposition date: 2019-07-19, release date: 2020-01-01, Last modification date: 2024-04-03)
Primary citation	Niu, B.,Appleby, T.C.,Wang, R.,Morar, M.,Voight, J.,Villasenor, A.G.,Clancy, S.,Wise, S.,Belzile, J.P.,Papalia, G.,Wong, M.,Brendza, K.M.,Lad, L.,Gross, M.L. Protein Footprinting and X-ray Crystallography Reveal the Interaction of PD-L1 and a Macrocyclic Peptide. Biochemistry, 59:541-551, 2020 Cited by PubMed: 31841311 DOI: 10.1021/acs.biochem.9b00822 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2 Å)

Structure validation