6PT1
Crystal Structure of Class D Beta-lactamase OXA-48 with Meropenem
Summary for 6PT1
Entry DOI | 10.2210/pdb6pt1/pdb |
Descriptor | Class D Carbapenemase OXA-48, CHLORIDE ION, (4R,5S)-3-{[(3S,5S)-5-(dimethylcarbamoyl)pyrrolidin-3-yl]sulfanyl}-5-[(2S,3R)-3-hydroxy-1-oxobutan-2-yl]-4-methyl-4,5-d ihydro-1H-pyrrole-2-carboxylic acid, ... (5 entities in total) |
Functional Keywords | carbapenemase, carbapenem, substrate, hydrolyzed product, hydrolase |
Biological source | Klebsiella pneumoniae |
Total number of polymer chains | 4 |
Total formula weight | 125246.34 |
Authors | Akhtar, A.,Chen, Y. (deposition date: 2019-07-14, release date: 2020-01-22, Last modification date: 2023-10-11) |
Primary citation | Akhtar, A.,Pemberton, O.A.,Chen, Y. Structural Basis for Substrate Specificity and Carbapenemase Activity of OXA-48 Class D beta-Lactamase. Acs Infect Dis., 6:261-271, 2020 Cited by PubMed: 31872762DOI: 10.1021/acsinfecdis.9b00304 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2 Å) |
Structure validation
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