6PT1

Crystal Structure of Class D Beta-lactamase OXA-48 with Meropenem

Summary for 6PT1

Entry DOI	10.2210/pdb6pt1/pdb
Descriptor	Class D Carbapenemase OXA-48, CHLORIDE ION, (4R,5S)-3-{[(3S,5S)-5-(dimethylcarbamoyl)pyrrolidin-3-yl]sulfanyl}-5-[(2S,3R)-3-hydroxy-1-oxobutan-2-yl]-4-methyl-4,5-d ihydro-1H-pyrrole-2-carboxylic acid, ... (5 entities in total)
Functional Keywords	carbapenemase, carbapenem, substrate, hydrolyzed product, hydrolase
Biological source	Klebsiella pneumoniae
Total number of polymer chains	4
Total formula weight	125246.34
Authors	Akhtar, A.,Chen, Y. (deposition date: 2019-07-14, release date: 2020-01-22, Last modification date: 2023-10-11)
Primary citation	Akhtar, A.,Pemberton, O.A.,Chen, Y. Structural Basis for Substrate Specificity and Carbapenemase Activity of OXA-48 Class D beta-Lactamase. Acs Infect Dis., 6:261-271, 2020 Cited by PubMed: 31872762 DOI: 10.1021/acsinfecdis.9b00304 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2 Å)

Structure validation