6PRD

S. aureus dihydrofolate reductase co-crystallized with para-methoxyphenyl-dimethyoxydihydropthalazine inhibitor and NADP(H)

Summary for 6PRD

Entry DOI	10.2210/pdb6prd/pdb
Descriptor	Dihydrofolate reductase, GLYCEROL, 3-{5-[(2,4-diaminopyrimidin-5-yl)methyl]-2,3-dimethoxyphenyl}-1-[(1S)-6,7-dimethoxy-1-(4-methoxyphenyl)-3,4-dihydrophthalazin-2(1H)-yl]propan-1-one, ... (5 entities in total)
Functional Keywords	dihydrofolate reductase, oxidoreductase-inhibitor complex, oxidoreductase/inhibitor
Biological source	Staphylococcus aureus
Total number of polymer chains	1
Total formula weight	20153.62
Authors	Bourne, C.R.,Thomas, L.M. (deposition date: 2019-07-10, release date: 2020-06-17, Last modification date: 2023-10-11)
Primary citation	Muddala, N.P.,White, J.C.,Nammalwar, B.,Pratt, I.,Thomas, L.M.,Bunce, R.A.,Berlin, K.D.,Bourne, C.R. Inhibitor design to target a unique feature in the folate pocket of Staphylococcus aureus dihydrofolate reductase. Eur.J.Med.Chem., 200:112412-112412, 2020 Cited by PubMed: 32502861 DOI: 10.1016/j.ejmech.2020.112412 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.01 Å)

Structure validation