Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004146 | molecular_function | dihydrofolate reductase activity |
| A | 0005829 | cellular_component | cytosol |
| A | 0006730 | biological_process | one-carbon metabolic process |
| A | 0016491 | molecular_function | oxidoreductase activity |
| A | 0046452 | biological_process | dihydrofolate metabolic process |
| A | 0046654 | biological_process | tetrahydrofolate biosynthetic process |
| A | 0046655 | biological_process | folic acid metabolic process |
| A | 0050661 | molecular_function | NADP binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 8 |
| Details | binding site for residue GOL A 401 |
| Chain | Residue |
| A | ILE102 |
| A | ASP103 |
| A | PRO125 |
| A | TYR126 |
| A | THR127 |
| A | ASP130 |
| A | TRP131 |
| A | ARG156 |
| site_id | AC2 |
| Number of Residues | 5 |
| Details | binding site for residue GOL A 402 |
| Chain | Residue |
| A | PRO125 |
| A | TYR126 |
| A | GLU132 |
| A | HOH511 |
| A | ARG12 |
| site_id | AC3 |
| Number of Residues | 19 |
| Details | binding site for residue OWG A 403 |
| Chain | Residue |
| A | LEU5 |
| A | VAL6 |
| A | ALA7 |
| A | LEU20 |
| A | PRO25 |
| A | ASP27 |
| A | LEU28 |
| A | LYS29 |
| A | VAL31 |
| A | LYS32 |
| A | SER49 |
| A | LEU54 |
| A | PRO55 |
| A | ASN56 |
| A | ARG57 |
| A | PHE92 |
| A | NAP404 |
| A | HOH502 |
| A | HOH557 |
| site_id | AC4 |
| Number of Residues | 32 |
| Details | binding site for residue NAP A 404 |
| Chain | Residue |
| A | VAL6 |
| A | ALA7 |
| A | ILE14 |
| A | GLY15 |
| A | ASN18 |
| A | GLN19 |
| A | LEU20 |
| A | GLY43 |
| A | ARG44 |
| A | LYS45 |
| A | THR46 |
| A | LEU62 |
| A | THR63 |
| A | SER64 |
| A | HIS77 |
| A | ILE79 |
| A | PHE92 |
| A | GLY93 |
| A | GLY94 |
| A | GLN95 |
| A | THR96 |
| A | LEU97 |
| A | GLU100 |
| A | THR121 |
| A | OWG403 |
| A | HOH510 |
| A | HOH524 |
| A | HOH532 |
| A | HOH542 |
| A | HOH544 |
| A | HOH547 |
| A | HOH579 |
Functional Information from PROSITE/UniProt
| site_id | PS00075 |
| Number of Residues | 23 |
| Details | DHFR_1 Dihydrofolate reductase (DHFR) domain signature. VIGfenqLPWhlpn.DlkhVkklS |
| Chain | Residue | Details |
| A | VAL13-SER35 | |
Functional Information from SwissProt/UniProt
| Chain | Residue | Details |
| A | LEU5 | |
| A | ASP27 | |
| A | SER49 | |
| A | ARG57 | |
| A | PHE92 | |
| Chain | Residue | Details |
| A | VAL6 | |
| A | ILE14 | |
| A | GLY43 | |
| A | LEU62 | |
| A | GLU100 | |
| A | THR121 | |
