6PQQ

Cryo-EM structure of human TRPA1 C621S mutant in the apo state

Summary for 6PQQ

Entry DOI	10.2210/pdb6pqq/pdb
EMDB information	20449 20450 20451
Descriptor	Transient receptor potential cation channel subfamily A member 1, 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine, [(2~{R})-1-[2-azanylethoxy(oxidanyl)phosphoryl]oxy-3-hexadecanoyloxy-propan-2-yl] (~{Z})-octadec-9-enoate (3 entities in total)
Functional Keywords	ion channel, trp channel, trpa channel, trpa1 channel, irritant sensing, apo state, membrane protein, transport protein
Biological source	Homo sapiens (Human)
Total number of polymer chains	4
Total formula weight	546358.46
Authors	Suo, Y.,Wang, Z.,Zubcevic, L.,Hsu, A.L.,He, Q.,Borgnia, M.J.,Ji, R.-R.,Lee, S.-Y. (deposition date: 2019-07-09, release date: 2020-01-08, Last modification date: 2024-03-20)
Primary citation	Suo, Y.,Wang, Z.,Zubcevic, L.,Hsu, A.L.,He, Q.,Borgnia, M.J.,Ji, R.R.,Lee, S.Y. Structural Insights into Electrophile Irritant Sensing by the Human TRPA1 Channel. Neuron, 105:882-, 2020 Cited by PubMed: 31866091 DOI: 10.1016/j.neuron.2019.11.023 PDB entries with the same primary citation
Experimental method	ELECTRON MICROSCOPY (2.81 Å)

Structure validation