6PQQ

Cryo-EM structure of human TRPA1 C621S mutant in the apo state

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, C, D (A, B, D, C)	Transient receptor potential cation channel subfamily A member 1	polymer	1152	131479.5	4	UniProt (O75762) Pfam (PF00023) Pfam (PF00520)	Homo sapiens (Human)	Ankyrin-like with transmembrane domains protein 1,Transformation-sensitive protein p120
2	AA, E, F, L, M... (C, A, B, D)	1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine	non-polymer		760.1	8	Chemie (LBN)
3	BA, CA, DA, EA, FA... (C, A, B, D)	[(2~{R})-1-[2-azanylethoxy(oxidanyl)phosphoryl]oxy-3-hexadecanoyloxy-propan-2-yl] (~{Z})-octadec-9-enoate	non-polymer		718.0	20	Chemie (6OU)

Sequence modifications

A, B, D, C: 2 - 1119 (UniProt: O75762)

PDB	External Database	Details
Met 0	-	expression tag
Ala 1	-	expression tag
Ser 621	Cys 621	engineered mutation
Ser 1120	-	expression tag
Asn 1121	-	expression tag
Ser 1122	-	expression tag
Leu 1123	-	expression tag
Glu 1124	-	expression tag
Val 1125	-	expression tag
Leu 1126	-	expression tag
Phe 1127	-	expression tag
Gln 1128	-	expression tag
Gly 1129	-	expression tag
Pro 1130	-	expression tag
Ala 1131	-	expression tag
Ala 1132	-	expression tag
Asp 1133	-	expression tag
Tyr 1134	-	expression tag
Lys 1135	-	expression tag
Asp 1136	-	expression tag
Asp 1137	-	expression tag
Asp 1138	-	expression tag
Asp 1139	-	expression tag
Lys 1140	-	expression tag
Ala 1141	-	expression tag
His 1142	-	expression tag
His 1143	-	expression tag
His 1144	-	expression tag
His 1145	-	expression tag
His 1146	-	expression tag
His 1147	-	expression tag
His 1148	-	expression tag
His 1149	-	expression tag
His 1150	-	expression tag
His 1151	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	525917.9
Non-Polymers*	Number of molecules	28
	Total formula weight	20440.5
All*	Total formula weight	546358.5

*Water molecules are not included.