6PQQ
Cryo-EM structure of human TRPA1 C621S mutant in the apo state
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0005216 | molecular_function | monoatomic ion channel activity |
A | 0005262 | molecular_function | calcium channel activity |
A | 0005886 | cellular_component | plasma membrane |
A | 0006811 | biological_process | monoatomic ion transport |
A | 0006816 | biological_process | calcium ion transport |
A | 0006874 | biological_process | intracellular calcium ion homeostasis |
A | 0007166 | biological_process | cell surface receptor signaling pathway |
A | 0009409 | biological_process | response to cold |
A | 0009410 | biological_process | response to xenobiotic stimulus |
A | 0014070 | biological_process | response to organic cyclic compound |
A | 0015267 | molecular_function | channel activity |
A | 0015278 | molecular_function | intracellularly gated calcium channel activity |
A | 0016020 | cellular_component | membrane |
A | 0019233 | biological_process | sensory perception of pain |
A | 0019722 | biological_process | calcium-mediated signaling |
A | 0032421 | cellular_component | stereocilium bundle |
A | 0042542 | biological_process | response to hydrogen peroxide |
A | 0042802 | molecular_function | identical protein binding |
A | 0048265 | biological_process | response to pain |
A | 0050955 | biological_process | thermoception |
A | 0050966 | biological_process | detection of mechanical stimulus involved in sensory perception of pain |
A | 0050968 | biological_process | detection of chemical stimulus involved in sensory perception of pain |
A | 0050974 | biological_process | detection of mechanical stimulus involved in sensory perception |
A | 0051289 | biological_process | protein homotetramerization |
A | 0055085 | biological_process | transmembrane transport |
A | 0070301 | biological_process | cellular response to hydrogen peroxide |
A | 0070588 | biological_process | calcium ion transmembrane transport |
A | 0071310 | biological_process | obsolete cellular response to organic substance |
A | 0097604 | molecular_function | temperature-gated cation channel activity |
B | 0005216 | molecular_function | monoatomic ion channel activity |
B | 0005262 | molecular_function | calcium channel activity |
B | 0005886 | cellular_component | plasma membrane |
B | 0006811 | biological_process | monoatomic ion transport |
B | 0006816 | biological_process | calcium ion transport |
B | 0006874 | biological_process | intracellular calcium ion homeostasis |
B | 0007166 | biological_process | cell surface receptor signaling pathway |
B | 0009409 | biological_process | response to cold |
B | 0009410 | biological_process | response to xenobiotic stimulus |
B | 0014070 | biological_process | response to organic cyclic compound |
B | 0015267 | molecular_function | channel activity |
B | 0015278 | molecular_function | intracellularly gated calcium channel activity |
B | 0016020 | cellular_component | membrane |
B | 0019233 | biological_process | sensory perception of pain |
B | 0019722 | biological_process | calcium-mediated signaling |
B | 0032421 | cellular_component | stereocilium bundle |
B | 0042542 | biological_process | response to hydrogen peroxide |
B | 0042802 | molecular_function | identical protein binding |
B | 0048265 | biological_process | response to pain |
B | 0050955 | biological_process | thermoception |
B | 0050966 | biological_process | detection of mechanical stimulus involved in sensory perception of pain |
B | 0050968 | biological_process | detection of chemical stimulus involved in sensory perception of pain |
B | 0050974 | biological_process | detection of mechanical stimulus involved in sensory perception |
B | 0051289 | biological_process | protein homotetramerization |
B | 0055085 | biological_process | transmembrane transport |
B | 0070301 | biological_process | cellular response to hydrogen peroxide |
B | 0070588 | biological_process | calcium ion transmembrane transport |
B | 0071310 | biological_process | obsolete cellular response to organic substance |
B | 0097604 | molecular_function | temperature-gated cation channel activity |
C | 0005216 | molecular_function | monoatomic ion channel activity |
C | 0005262 | molecular_function | calcium channel activity |
C | 0005886 | cellular_component | plasma membrane |
C | 0006811 | biological_process | monoatomic ion transport |
C | 0006816 | biological_process | calcium ion transport |
C | 0006874 | biological_process | intracellular calcium ion homeostasis |
C | 0007166 | biological_process | cell surface receptor signaling pathway |
C | 0009409 | biological_process | response to cold |
C | 0009410 | biological_process | response to xenobiotic stimulus |
C | 0014070 | biological_process | response to organic cyclic compound |
C | 0015267 | molecular_function | channel activity |
C | 0015278 | molecular_function | intracellularly gated calcium channel activity |
C | 0016020 | cellular_component | membrane |
C | 0019233 | biological_process | sensory perception of pain |
C | 0019722 | biological_process | calcium-mediated signaling |
C | 0032421 | cellular_component | stereocilium bundle |
C | 0042542 | biological_process | response to hydrogen peroxide |
C | 0042802 | molecular_function | identical protein binding |
C | 0048265 | biological_process | response to pain |
C | 0050955 | biological_process | thermoception |
C | 0050966 | biological_process | detection of mechanical stimulus involved in sensory perception of pain |
C | 0050968 | biological_process | detection of chemical stimulus involved in sensory perception of pain |
C | 0050974 | biological_process | detection of mechanical stimulus involved in sensory perception |
C | 0051289 | biological_process | protein homotetramerization |
C | 0055085 | biological_process | transmembrane transport |
C | 0070301 | biological_process | cellular response to hydrogen peroxide |
C | 0070588 | biological_process | calcium ion transmembrane transport |
C | 0071310 | biological_process | obsolete cellular response to organic substance |
C | 0097604 | molecular_function | temperature-gated cation channel activity |
D | 0005216 | molecular_function | monoatomic ion channel activity |
D | 0005262 | molecular_function | calcium channel activity |
D | 0005886 | cellular_component | plasma membrane |
D | 0006811 | biological_process | monoatomic ion transport |
D | 0006816 | biological_process | calcium ion transport |
D | 0006874 | biological_process | intracellular calcium ion homeostasis |
D | 0007166 | biological_process | cell surface receptor signaling pathway |
D | 0009409 | biological_process | response to cold |
D | 0009410 | biological_process | response to xenobiotic stimulus |
D | 0014070 | biological_process | response to organic cyclic compound |
D | 0015267 | molecular_function | channel activity |
D | 0015278 | molecular_function | intracellularly gated calcium channel activity |
D | 0016020 | cellular_component | membrane |
D | 0019233 | biological_process | sensory perception of pain |
D | 0019722 | biological_process | calcium-mediated signaling |
D | 0032421 | cellular_component | stereocilium bundle |
D | 0042542 | biological_process | response to hydrogen peroxide |
D | 0042802 | molecular_function | identical protein binding |
D | 0048265 | biological_process | response to pain |
D | 0050955 | biological_process | thermoception |
D | 0050966 | biological_process | detection of mechanical stimulus involved in sensory perception of pain |
D | 0050968 | biological_process | detection of chemical stimulus involved in sensory perception of pain |
D | 0050974 | biological_process | detection of mechanical stimulus involved in sensory perception |
D | 0051289 | biological_process | protein homotetramerization |
D | 0055085 | biological_process | transmembrane transport |
D | 0070301 | biological_process | cellular response to hydrogen peroxide |
D | 0070588 | biological_process | calcium ion transmembrane transport |
D | 0071310 | biological_process | obsolete cellular response to organic substance |
D | 0097604 | molecular_function | temperature-gated cation channel activity |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 5 |
Details | binding site for residue LBN A 1201 |
Chain | Residue |
A | TRP711 |
A | PHE853 |
A | GLU854 |
A | ASN855 |
A | CYS856 |
site_id | AC2 |
Number of Residues | 8 |
Details | binding site for residue LBN A 1202 |
Chain | Residue |
A | GLU864 |
A | LYS868 |
A | LEU871 |
A | THR874 |
A | ASP802 |
A | ILE803 |
A | GLN851 |
A | ILE860 |
site_id | AC3 |
Number of Residues | 2 |
Details | binding site for residue 6OU A 1203 |
Chain | Residue |
A | LEU871 |
A | THR874 |
site_id | AC4 |
Number of Residues | 4 |
Details | binding site for residue 6OU A 1204 |
Chain | Residue |
A | THR813 |
A | HIS829 |
A | GLN833 |
B | 6OU1206 |
site_id | AC5 |
Number of Residues | 5 |
Details | binding site for residue 6OU A 1205 |
Chain | Residue |
A | ILE878 |
A | LEU882 |
A | LEU902 |
B | 6OU1206 |
D | 6OU1207 |
site_id | AC6 |
Number of Residues | 8 |
Details | binding site for residue 6OU A 1206 |
Chain | Residue |
A | TYR926 |
A | VAL935 |
A | PHE938 |
A | VAL942 |
D | SER900 |
D | LEU902 |
D | 6OU1204 |
D | 6OU1205 |
site_id | AC7 |
Number of Residues | 6 |
Details | binding site for residue 6OU A 1207 |
Chain | Residue |
A | ILE731 |
A | VAL738 |
A | ASN739 |
A | ASN766 |
A | LEU769 |
B | 6OU1205 |
site_id | AC8 |
Number of Residues | 5 |
Details | binding site for residue LBN B 1201 |
Chain | Residue |
B | TRP711 |
B | PHE853 |
B | GLU854 |
B | ASN855 |
B | CYS856 |
site_id | AC9 |
Number of Residues | 9 |
Details | binding site for residue LBN B 1202 |
Chain | Residue |
B | ASP802 |
B | ILE803 |
B | GLN851 |
B | ILE860 |
B | GLU864 |
B | LYS868 |
B | LEU871 |
B | THR874 |
C | 6OU1206 |
site_id | AD1 |
Number of Residues | 2 |
Details | binding site for residue 6OU B 1203 |
Chain | Residue |
B | LEU871 |
B | THR874 |
site_id | AD2 |
Number of Residues | 4 |
Details | binding site for residue 6OU B 1204 |
Chain | Residue |
B | THR813 |
B | HIS829 |
B | GLN833 |
C | 6OU1206 |
site_id | AD3 |
Number of Residues | 5 |
Details | binding site for residue 6OU B 1205 |
Chain | Residue |
A | 6OU1207 |
B | ILE878 |
B | LEU882 |
B | LEU902 |
C | 6OU1206 |
site_id | AD4 |
Number of Residues | 7 |
Details | binding site for residue 6OU B 1206 |
Chain | Residue |
A | SER900 |
A | 6OU1204 |
A | 6OU1205 |
B | TYR926 |
B | VAL935 |
B | PHE938 |
B | VAL942 |
site_id | AD5 |
Number of Residues | 6 |
Details | binding site for residue 6OU B 1207 |
Chain | Residue |
B | ILE731 |
B | VAL738 |
B | ASN739 |
B | ASN766 |
B | LEU769 |
C | 6OU1205 |
site_id | AD6 |
Number of Residues | 5 |
Details | binding site for residue LBN D 1201 |
Chain | Residue |
D | TRP711 |
D | PHE853 |
D | GLU854 |
D | ASN855 |
D | CYS856 |
site_id | AD7 |
Number of Residues | 10 |
Details | binding site for residue LBN D 1202 |
Chain | Residue |
A | LEU936 |
A | ILE946 |
D | ASP802 |
D | ILE803 |
D | GLN851 |
D | ILE860 |
D | GLU864 |
D | LYS868 |
D | LEU871 |
D | THR874 |
site_id | AD8 |
Number of Residues | 3 |
Details | binding site for residue 6OU D 1203 |
Chain | Residue |
C | CYS1025 |
D | LEU871 |
D | THR874 |
site_id | AD9 |
Number of Residues | 4 |
Details | binding site for residue 6OU D 1204 |
Chain | Residue |
A | 6OU1206 |
D | THR813 |
D | HIS829 |
D | GLN833 |
site_id | AE1 |
Number of Residues | 5 |
Details | binding site for residue 6OU D 1205 |
Chain | Residue |
C | 6OU1207 |
D | ILE878 |
D | LEU882 |
D | LEU902 |
A | 6OU1206 |
site_id | AE2 |
Number of Residues | 8 |
Details | binding site for residue 6OU D 1206 |
Chain | Residue |
C | LEU902 |
C | LBN1202 |
C | 6OU1204 |
C | 6OU1205 |
D | TYR926 |
D | VAL935 |
D | PHE938 |
D | VAL942 |
site_id | AE3 |
Number of Residues | 6 |
Details | binding site for residue 6OU D 1207 |
Chain | Residue |
A | 6OU1205 |
D | ILE731 |
D | VAL738 |
D | ASN739 |
D | ASN766 |
D | LEU769 |
site_id | AE4 |
Number of Residues | 6 |
Details | binding site for residue LBN C 1201 |
Chain | Residue |
C | TRP711 |
C | PHE853 |
C | GLU854 |
C | ASN855 |
C | CYS856 |
D | PHE879 |
site_id | AE5 |
Number of Residues | 13 |
Details | binding site for residue LBN C 1202 |
Chain | Residue |
C | ASP802 |
C | ILE803 |
C | GLN851 |
C | ILE860 |
C | GLU864 |
C | LYS868 |
C | LEU871 |
C | THR874 |
D | LEU936 |
D | ALA939 |
D | SER943 |
D | PHE947 |
D | 6OU1206 |
site_id | AE6 |
Number of Residues | 2 |
Details | binding site for residue 6OU C 1203 |
Chain | Residue |
C | LEU871 |
C | THR874 |
site_id | AE7 |
Number of Residues | 4 |
Details | binding site for residue 6OU C 1204 |
Chain | Residue |
C | THR813 |
C | HIS829 |
C | GLN833 |
D | 6OU1206 |
site_id | AE8 |
Number of Residues | 5 |
Details | binding site for residue 6OU C 1205 |
Chain | Residue |
B | 6OU1207 |
C | ILE878 |
C | LEU882 |
C | LEU902 |
D | 6OU1206 |
site_id | AE9 |
Number of Residues | 8 |
Details | binding site for residue 6OU C 1206 |
Chain | Residue |
B | SER900 |
B | LBN1202 |
B | 6OU1204 |
B | 6OU1205 |
C | TYR926 |
C | VAL935 |
C | PHE938 |
C | VAL942 |
site_id | AF1 |
Number of Residues | 6 |
Details | binding site for residue 6OU C 1207 |
Chain | Residue |
C | ILE731 |
C | VAL738 |
C | ASN739 |
C | ASN766 |
C | LEU769 |
D | 6OU1205 |
Functional Information from PROSITE/UniProt
site_id | PS00018 |
Number of Residues | 13 |
Details | EF_HAND_1 EF-hand calcium-binding domain. DISDTRLLNegDL |
Chain | Residue | Details |
A | ASP468-LEU480 |
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 80 |
Details | TRANSMEM: Helical; Name=1 => ECO:0000305|PubMed:25855297 |
Chain | Residue | Details |
A | MET720-ILE740 | |
B | MET720-ILE740 | |
D | MET720-ILE740 | |
C | MET720-ILE740 |
site_id | SWS_FT_FI2 |
Number of Residues | 176 |
Details | TOPO_DOM: Extracellular => ECO:0000305|PubMed:25855297 |
Chain | Residue | Details |
A | LYS741-THR764 | |
D | GLU825-HIS829 | |
D | GLN895-PRO901 | |
D | LEU923-PRO934 | |
C | LYS741-THR764 | |
C | GLU825-HIS829 | |
C | GLN895-PRO901 | |
C | LEU923-PRO934 | |
A | GLU825-HIS829 | |
A | GLN895-PRO901 | |
A | LEU923-PRO934 | |
B | LYS741-THR764 | |
B | GLU825-HIS829 | |
B | GLN895-PRO901 | |
B | LEU923-PRO934 | |
D | LYS741-THR764 |
site_id | SWS_FT_FI3 |
Number of Residues | 80 |
Details | TRANSMEM: Helical; Name=2 => ECO:0000305|PubMed:25855297 |
Chain | Residue | Details |
A | THR765-TYR785 | |
B | THR765-TYR785 | |
D | THR765-TYR785 | |
C | THR765-TYR785 |
site_id | SWS_FT_FI4 |
Number of Residues | 804 |
Details | TOPO_DOM: Cytoplasmic => ECO:0000305|PubMed:25855297 |
Chain | Residue | Details |
A | CYS786-ILE803 | |
C | CYS786-ILE803 | |
C | GLN851-SER873 | |
C | ILE957-PRO1119 | |
A | GLN851-SER873 | |
A | ILE957-PRO1119 | |
B | CYS786-ILE803 | |
B | GLN851-SER873 | |
B | ILE957-PRO1119 | |
D | CYS786-ILE803 | |
D | GLN851-SER873 | |
D | ILE957-PRO1119 |
site_id | SWS_FT_FI5 |
Number of Residues | 80 |
Details | TRANSMEM: Helical; Name=3 => ECO:0000305|PubMed:25855297 |
Chain | Residue | Details |
A | SER804-VAL824 | |
B | SER804-VAL824 | |
D | SER804-VAL824 | |
C | SER804-VAL824 |
site_id | SWS_FT_FI6 |
Number of Residues | 80 |
Details | TRANSMEM: Helical; Name=4 => ECO:0000305|PubMed:25855297 |
Chain | Residue | Details |
A | LEU830-LEU850 | |
B | LEU830-LEU850 | |
D | LEU830-LEU850 | |
C | LEU830-LEU850 |
site_id | SWS_FT_FI7 |
Number of Residues | 80 |
Details | TRANSMEM: Helical; Name=5 => ECO:0000305|PubMed:25855297 |
Chain | Residue | Details |
A | THR874-LEU894 | |
B | THR874-LEU894 | |
D | THR874-LEU894 | |
C | THR874-LEU894 |
site_id | SWS_FT_FI8 |
Number of Residues | 80 |
Details | INTRAMEM: Pore-forming => ECO:0000305|PubMed:25855297 |
Chain | Residue | Details |
A | LEU902-PHE922 | |
B | LEU902-PHE922 | |
D | LEU902-PHE922 | |
C | LEU902-PHE922 |
site_id | SWS_FT_FI9 |
Number of Residues | 84 |
Details | TRANSMEM: Helical; Name=6 => ECO:0000305|PubMed:25855297 |
Chain | Residue | Details |
A | VAL935-LEU956 | |
B | VAL935-LEU956 | |
D | VAL935-LEU956 | |
C | VAL935-LEU956 |
site_id | SWS_FT_FI10 |
Number of Residues | 8 |
Details | BINDING: covalent => ECO:0000250|UniProtKB:Q8BLA8 |
Chain | Residue | Details |
A | CYS414 | |
A | CYS421 | |
B | CYS414 | |
B | CYS421 | |
D | CYS414 | |
D | CYS421 | |
C | CYS414 | |
C | CYS421 |
site_id | SWS_FT_FI11 |
Number of Residues | 4 |
Details | BINDING: covalent; Cys highly reactive => ECO:0000250|UniProtKB:Q8BLA8, ECO:0000305|PubMed:17164327, ECO:0000305|PubMed:27241698 |
Chain | Residue | Details |
A | SER621 | |
B | SER621 | |
D | SER621 | |
C | SER621 |
site_id | SWS_FT_FI12 |
Number of Residues | 8 |
Details | BINDING: covalent => ECO:0000305|PubMed:17164327 |
Chain | Residue | Details |
A | CYS641 | |
A | LYS710 | |
B | CYS641 | |
B | LYS710 | |
D | CYS641 | |
D | LYS710 | |
C | CYS641 | |
C | LYS710 |
site_id | SWS_FT_FI13 |
Number of Residues | 4 |
Details | BINDING: covalent => ECO:0000305|PubMed:17164327, ECO:0000305|PubMed:27241698 |
Chain | Residue | Details |
A | CYS665 | |
B | CYS665 | |
D | CYS665 | |
C | CYS665 |
site_id | SWS_FT_FI14 |
Number of Residues | 4 |
Details | BINDING: BINDING => ECO:0000305|PubMed:25855297 |
Chain | Residue | Details |
A | LYS1046 | |
B | LYS1046 | |
D | LYS1046 | |
C | LYS1046 |
site_id | SWS_FT_FI15 |
Number of Residues | 4 |
Details | SITE: Required for C-621 reactivity => ECO:0000269|PubMed:27241698 |
Chain | Residue | Details |
A | LYS620 | |
B | LYS620 | |
D | LYS620 | |
C | LYS620 |
site_id | SWS_FT_FI16 |
Number of Residues | 4 |
Details | SITE: Key residue for activation by the scorpion wasabi receptor toxin => ECO:0000269|PubMed:31447178 |
Chain | Residue | Details |
A | PRO622 | |
B | PRO622 | |
D | PRO622 | |
C | PRO622 |
site_id | SWS_FT_FI17 |
Number of Residues | 8 |
Details | SITE: Important residue for activation by the scorpion wasabi receptor toxin => ECO:0000269|PubMed:31447178 |
Chain | Residue | Details |
A | MET634 | |
A | THR646 | |
B | MET634 | |
B | THR646 | |
D | MET634 | |
D | THR646 | |
C | MET634 | |
C | THR646 |
site_id | SWS_FT_FI18 |
Number of Residues | 4 |
Details | MOD_RES: 4-hydroxyproline; by EGLN1; transient; in normoxia and hyperoxia => ECO:0000269|PubMed:21873995 |
Chain | Residue | Details |
A | PRO394 | |
B | PRO394 | |
D | PRO394 | |
C | PRO394 |
site_id | SWS_FT_FI19 |
Number of Residues | 8 |
Details | MOD_RES: Cysteine sulfenic acid (-SOH); transient; in hyperoxia => ECO:0000305|PubMed:21873995 |
Chain | Residue | Details |
A | CYS633 | |
A | CYS856 | |
B | CYS633 | |
B | CYS856 | |
D | CYS633 | |
D | CYS856 | |
C | CYS633 | |
C | CYS856 |
site_id | SWS_FT_FI20 |
Number of Residues | 8 |
Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255 |
Chain | Residue | Details |
A | ASN747 | |
A | ASN753 | |
B | ASN747 | |
B | ASN753 | |
D | ASN747 | |
D | ASN753 | |
C | ASN747 | |
C | ASN753 |