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SummaryStructural detailsExperimental detailsFunctional detailsSequence NeighborHistoryDownloads

6PQQ

Cryo-EM structure of human TRPA1 C621S mutant in the apo state

Functional Information from GO Data
ChainGOidnamespacecontents
A0003008biological_processsystem process
A0005216molecular_functionmonoatomic ion channel activity
A0005245molecular_functionvoltage-gated calcium channel activity
A0005262molecular_functioncalcium channel activity
A0005886cellular_componentplasma membrane
A0006811biological_processmonoatomic ion transport
A0006816biological_processcalcium ion transport
A0006874biological_processintracellular calcium ion homeostasis
A0007166biological_processcell surface receptor signaling pathway
A0009409biological_processresponse to cold
A0014832biological_processurinary bladder smooth muscle contraction
A0015267molecular_functionchannel activity
A0015278molecular_functionintracellularly gated calcium channel activity
A0016020cellular_componentmembrane
A0016324cellular_componentapical plasma membrane
A0019233biological_processsensory perception of pain
A0019722biological_processcalcium-mediated signaling
A0022836molecular_functiongated channel activity
A0030424cellular_componentaxon
A0032421cellular_componentstereocilium bundle
A0033554biological_processcellular response to stress
A0034220biological_processmonoatomic ion transmembrane transport
A0034605biological_processcellular response to heat
A0035774biological_processpositive regulation of insulin secretion involved in cellular response to glucose stimulus
A0042802molecular_functionidentical protein binding
A0050955biological_processthermoception
A0050968biological_processdetection of chemical stimulus involved in sensory perception of pain
A0050974biological_processdetection of mechanical stimulus involved in sensory perception
A0051289biological_processprotein homotetramerization
A0055085biological_processtransmembrane transport
A0070301biological_processcellular response to hydrogen peroxide
A0070417biological_processcellular response to cold
A0070588biological_processcalcium ion transmembrane transport
A0071240biological_processcellular response to food
A0071244biological_processcellular response to carbon dioxide
A0071313biological_processcellular response to caffeine
A0097237biological_processcellular response to toxic substance
A0097553biological_processcalcium ion transmembrane import into cytosol
A0097604molecular_functiontemperature-gated cation channel activity
A0098908biological_processregulation of neuronal action potential
A1901701biological_processcellular response to oxygen-containing compound
A1903522biological_processregulation of blood circulation
A1903793biological_processpositive regulation of monoatomic anion transport
A1990760molecular_functionosmolarity-sensing monoatomic cation channel activity
B0003008biological_processsystem process
B0005216molecular_functionmonoatomic ion channel activity
B0005245molecular_functionvoltage-gated calcium channel activity
B0005262molecular_functioncalcium channel activity
B0005886cellular_componentplasma membrane
B0006811biological_processmonoatomic ion transport
B0006816biological_processcalcium ion transport
B0006874biological_processintracellular calcium ion homeostasis
B0007166biological_processcell surface receptor signaling pathway
B0009409biological_processresponse to cold
B0014832biological_processurinary bladder smooth muscle contraction
B0015267molecular_functionchannel activity
B0015278molecular_functionintracellularly gated calcium channel activity
B0016020cellular_componentmembrane
B0016324cellular_componentapical plasma membrane
B0019233biological_processsensory perception of pain
B0019722biological_processcalcium-mediated signaling
B0022836molecular_functiongated channel activity
B0030424cellular_componentaxon
B0032421cellular_componentstereocilium bundle
B0033554biological_processcellular response to stress
B0034220biological_processmonoatomic ion transmembrane transport
B0034605biological_processcellular response to heat
B0035774biological_processpositive regulation of insulin secretion involved in cellular response to glucose stimulus
B0042802molecular_functionidentical protein binding
B0050955biological_processthermoception
B0050968biological_processdetection of chemical stimulus involved in sensory perception of pain
B0050974biological_processdetection of mechanical stimulus involved in sensory perception
B0051289biological_processprotein homotetramerization
B0055085biological_processtransmembrane transport
B0070301biological_processcellular response to hydrogen peroxide
B0070417biological_processcellular response to cold
B0070588biological_processcalcium ion transmembrane transport
B0071240biological_processcellular response to food
B0071244biological_processcellular response to carbon dioxide
B0071313biological_processcellular response to caffeine
B0097237biological_processcellular response to toxic substance
B0097553biological_processcalcium ion transmembrane import into cytosol
B0097604molecular_functiontemperature-gated cation channel activity
B0098908biological_processregulation of neuronal action potential
B1901701biological_processcellular response to oxygen-containing compound
B1903522biological_processregulation of blood circulation
B1903793biological_processpositive regulation of monoatomic anion transport
B1990760molecular_functionosmolarity-sensing monoatomic cation channel activity
C0003008biological_processsystem process
C0005216molecular_functionmonoatomic ion channel activity
C0005245molecular_functionvoltage-gated calcium channel activity
C0005262molecular_functioncalcium channel activity
C0005886cellular_componentplasma membrane
C0006811biological_processmonoatomic ion transport
C0006816biological_processcalcium ion transport
C0006874biological_processintracellular calcium ion homeostasis
C0007166biological_processcell surface receptor signaling pathway
C0009409biological_processresponse to cold
C0014832biological_processurinary bladder smooth muscle contraction
C0015267molecular_functionchannel activity
C0015278molecular_functionintracellularly gated calcium channel activity
C0016020cellular_componentmembrane
C0016324cellular_componentapical plasma membrane
C0019233biological_processsensory perception of pain
C0019722biological_processcalcium-mediated signaling
C0022836molecular_functiongated channel activity
C0030424cellular_componentaxon
C0032421cellular_componentstereocilium bundle
C0033554biological_processcellular response to stress
C0034220biological_processmonoatomic ion transmembrane transport
C0034605biological_processcellular response to heat
C0035774biological_processpositive regulation of insulin secretion involved in cellular response to glucose stimulus
C0042802molecular_functionidentical protein binding
C0050955biological_processthermoception
C0050968biological_processdetection of chemical stimulus involved in sensory perception of pain
C0050974biological_processdetection of mechanical stimulus involved in sensory perception
C0051289biological_processprotein homotetramerization
C0055085biological_processtransmembrane transport
C0070301biological_processcellular response to hydrogen peroxide
C0070417biological_processcellular response to cold
C0070588biological_processcalcium ion transmembrane transport
C0071240biological_processcellular response to food
C0071244biological_processcellular response to carbon dioxide
C0071313biological_processcellular response to caffeine
C0097237biological_processcellular response to toxic substance
C0097553biological_processcalcium ion transmembrane import into cytosol
C0097604molecular_functiontemperature-gated cation channel activity
C0098908biological_processregulation of neuronal action potential
C1901701biological_processcellular response to oxygen-containing compound
C1903522biological_processregulation of blood circulation
C1903793biological_processpositive regulation of monoatomic anion transport
C1990760molecular_functionosmolarity-sensing monoatomic cation channel activity
D0003008biological_processsystem process
D0005216molecular_functionmonoatomic ion channel activity
D0005245molecular_functionvoltage-gated calcium channel activity
D0005262molecular_functioncalcium channel activity
D0005886cellular_componentplasma membrane
D0006811biological_processmonoatomic ion transport
D0006816biological_processcalcium ion transport
D0006874biological_processintracellular calcium ion homeostasis
D0007166biological_processcell surface receptor signaling pathway
D0009409biological_processresponse to cold
D0014832biological_processurinary bladder smooth muscle contraction
D0015267molecular_functionchannel activity
D0015278molecular_functionintracellularly gated calcium channel activity
D0016020cellular_componentmembrane
D0016324cellular_componentapical plasma membrane
D0019233biological_processsensory perception of pain
D0019722biological_processcalcium-mediated signaling
D0022836molecular_functiongated channel activity
D0030424cellular_componentaxon
D0032421cellular_componentstereocilium bundle
D0033554biological_processcellular response to stress
D0034220biological_processmonoatomic ion transmembrane transport
D0034605biological_processcellular response to heat
D0035774biological_processpositive regulation of insulin secretion involved in cellular response to glucose stimulus
D0042802molecular_functionidentical protein binding
D0050955biological_processthermoception
D0050968biological_processdetection of chemical stimulus involved in sensory perception of pain
D0050974biological_processdetection of mechanical stimulus involved in sensory perception
D0051289biological_processprotein homotetramerization
D0055085biological_processtransmembrane transport
D0070301biological_processcellular response to hydrogen peroxide
D0070417biological_processcellular response to cold
D0070588biological_processcalcium ion transmembrane transport
D0071240biological_processcellular response to food
D0071244biological_processcellular response to carbon dioxide
D0071313biological_processcellular response to caffeine
D0097237biological_processcellular response to toxic substance
D0097553biological_processcalcium ion transmembrane import into cytosol
D0097604molecular_functiontemperature-gated cation channel activity
D0098908biological_processregulation of neuronal action potential
D1901701biological_processcellular response to oxygen-containing compound
D1903522biological_processregulation of blood circulation
D1903793biological_processpositive regulation of monoatomic anion transport
D1990760molecular_functionosmolarity-sensing monoatomic cation channel activity
Functional Information from PDB Data
site_idAC1
Number of Residues5
Detailsbinding site for residue LBN A 1201
ChainResidue
ATRP711
APHE853
AGLU854
AASN855
ACYS856
site_idAC2
Number of Residues8
Detailsbinding site for residue LBN A 1202
ChainResidue
AGLU864
ALYS868
ALEU871
ATHR874
AASP802
AILE803
AGLN851
AILE860
site_idAC3
Number of Residues2
Detailsbinding site for residue 6OU A 1203
ChainResidue
ALEU871
ATHR874
site_idAC4
Number of Residues4
Detailsbinding site for residue 6OU A 1204
ChainResidue
ATHR813
AHIS829
AGLN833
B6OU1206
site_idAC5
Number of Residues5
Detailsbinding site for residue 6OU A 1205
ChainResidue
AILE878
ALEU882
ALEU902
B6OU1206
D6OU1207
site_idAC6
Number of Residues8
Detailsbinding site for residue 6OU A 1206
ChainResidue
ATYR926
AVAL935
APHE938
AVAL942
DSER900
DLEU902
D6OU1204
D6OU1205
site_idAC7
Number of Residues6
Detailsbinding site for residue 6OU A 1207
ChainResidue
AILE731
AVAL738
AASN739
AASN766
ALEU769
B6OU1205
site_idAC8
Number of Residues5
Detailsbinding site for residue LBN B 1201
ChainResidue
BTRP711
BPHE853
BGLU854
BASN855
BCYS856
site_idAC9
Number of Residues9
Detailsbinding site for residue LBN B 1202
ChainResidue
BASP802
BILE803
BGLN851
BILE860
BGLU864
BLYS868
BLEU871
BTHR874
C6OU1206
site_idAD1
Number of Residues2
Detailsbinding site for residue 6OU B 1203
ChainResidue
BLEU871
BTHR874
site_idAD2
Number of Residues4
Detailsbinding site for residue 6OU B 1204
ChainResidue
BTHR813
BHIS829
BGLN833
C6OU1206
site_idAD3
Number of Residues5
Detailsbinding site for residue 6OU B 1205
ChainResidue
A6OU1207
BILE878
BLEU882
BLEU902
C6OU1206
site_idAD4
Number of Residues7
Detailsbinding site for residue 6OU B 1206
ChainResidue
ASER900
A6OU1204
A6OU1205
BTYR926
BVAL935
BPHE938
BVAL942
site_idAD5
Number of Residues6
Detailsbinding site for residue 6OU B 1207
ChainResidue
BILE731
BVAL738
BASN739
BASN766
BLEU769
C6OU1205
site_idAD6
Number of Residues5
Detailsbinding site for residue LBN D 1201
ChainResidue
DTRP711
DPHE853
DGLU854
DASN855
DCYS856
site_idAD7
Number of Residues10
Detailsbinding site for residue LBN D 1202
ChainResidue
ALEU936
AILE946
DASP802
DILE803
DGLN851
DILE860
DGLU864
DLYS868
DLEU871
DTHR874
site_idAD8
Number of Residues3
Detailsbinding site for residue 6OU D 1203
ChainResidue
CCYS1025
DLEU871
DTHR874
site_idAD9
Number of Residues4
Detailsbinding site for residue 6OU D 1204
ChainResidue
A6OU1206
DTHR813
DHIS829
DGLN833
site_idAE1
Number of Residues5
Detailsbinding site for residue 6OU D 1205
ChainResidue
C6OU1207
DILE878
DLEU882
DLEU902
A6OU1206
site_idAE2
Number of Residues8
Detailsbinding site for residue 6OU D 1206
ChainResidue
CLEU902
CLBN1202
C6OU1204
C6OU1205
DTYR926
DVAL935
DPHE938
DVAL942
site_idAE3
Number of Residues6
Detailsbinding site for residue 6OU D 1207
ChainResidue
A6OU1205
DILE731
DVAL738
DASN739
DASN766
DLEU769
site_idAE4
Number of Residues6
Detailsbinding site for residue LBN C 1201
ChainResidue
CTRP711
CPHE853
CGLU854
CASN855
CCYS856
DPHE879
site_idAE5
Number of Residues13
Detailsbinding site for residue LBN C 1202
ChainResidue
CASP802
CILE803
CGLN851
CILE860
CGLU864
CLYS868
CLEU871
CTHR874
DLEU936
DALA939
DSER943
DPHE947
D6OU1206
site_idAE6
Number of Residues2
Detailsbinding site for residue 6OU C 1203
ChainResidue
CLEU871
CTHR874
site_idAE7
Number of Residues4
Detailsbinding site for residue 6OU C 1204
ChainResidue
CTHR813
CHIS829
CGLN833
D6OU1206
site_idAE8
Number of Residues5
Detailsbinding site for residue 6OU C 1205
ChainResidue
B6OU1207
CILE878
CLEU882
CLEU902
D6OU1206
site_idAE9
Number of Residues8
Detailsbinding site for residue 6OU C 1206
ChainResidue
BSER900
BLBN1202
B6OU1204
B6OU1205
CTYR926
CVAL935
CPHE938
CVAL942
site_idAF1
Number of Residues6
Detailsbinding site for residue 6OU C 1207
ChainResidue
CILE731
CVAL738
CASN739
CASN766
CLEU769
D6OU1205
Functional Information from PROSITE/UniProt
site_idPS00018
Number of Residues13
DetailsEF_HAND_1 EF-hand calcium-binding domain. DISDTRLLNegDL
ChainResidueDetails
AASP468-LEU480
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues80
DetailsTransmembrane: {"description":"Helical; Name=1","evidences":[{"source":"PubMed","id":"31866091","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6PQO","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI2
Number of Residues100
DetailsTransmembrane: {"description":"Helical; Name=2","evidences":[{"source":"PubMed","id":"31866091","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6PQO","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI3
Number of Residues60
DetailsTopological domain: {"description":"Cytoplasmic","evidences":[{"evidenceCode":"ECO:0000305"}]}
ChainResidueDetails
site_idSWS_FT_FI4
Number of Residues96
DetailsTransmembrane: {"description":"Helical; Name=3","evidences":[{"source":"PubMed","id":"31866091","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6PQO","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI5
Number of Residues92
DetailsTopological domain: {"description":"Extracellular","evidences":[{"evidenceCode":"ECO:0000305"}]}
ChainResidueDetails
site_idSWS_FT_FI6
Number of Residues80
DetailsTransmembrane: {"description":"Helical; Name=4","evidences":[{"source":"PubMed","id":"31866091","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6PQO","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI7
Number of Residues116
DetailsTransmembrane: {"description":"Helical; Name=5","evidences":[{"source":"PubMed","id":"31866091","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6PQO","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI8
Number of Residues80
DetailsIntramembrane: {"description":"Pore-forming","evidences":[{"source":"PubMed","id":"31866091","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6PQO","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI9
Number of Residues104
DetailsTransmembrane: {"description":"Helical; Name=6","evidences":[{"source":"PubMed","id":"31866091","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6PQO","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI10
Number of Residues116
DetailsRepeat: {"description":"ANK 13","evidences":[{"evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"25855297","evidenceCode":"ECO:0000305"}]}
ChainResidueDetails
site_idSWS_FT_FI11
Number of Residues116
DetailsRepeat: {"description":"ANK 14","evidences":[{"evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"25855297","evidenceCode":"ECO:0000305"}]}
ChainResidueDetails
site_idSWS_FT_FI12
Number of Residues116
DetailsRepeat: {"description":"ANK 15","evidences":[{"evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"25855297","evidenceCode":"ECO:0000305"}]}
ChainResidueDetails
site_idSWS_FT_FI13
Number of Residues120
DetailsRepeat: {"description":"ANK 16","evidences":[{"evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"25855297","evidenceCode":"ECO:0000305"}]}
ChainResidueDetails
site_idSWS_FT_FI14
Number of Residues116
DetailsCoiled coil: {"evidences":[{"source":"PubMed","id":"25855297","evidenceCode":"ECO:0000305"}]}
ChainResidueDetails
site_idSWS_FT_FI15
Number of Residues4
DetailsBinding site: {"description":"covalent; Cys highly reactive","evidences":[{"source":"UniProtKB","id":"Q8BLA8","evidenceCode":"ECO:0000250"},{"source":"PubMed","id":"17164327","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"27241698","evidenceCode":"ECO:0000305"}]}
ChainResidueDetails
site_idSWS_FT_FI16
Number of Residues8
DetailsBinding site: {"description":"covalent","evidences":[{"source":"PubMed","id":"17164327","evidenceCode":"ECO:0000305"}]}
ChainResidueDetails
site_idSWS_FT_FI17
Number of Residues4
DetailsBinding site: {"description":"covalent","evidences":[{"source":"PubMed","id":"17164327","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"27241698","evidenceCode":"ECO:0000305"}]}
ChainResidueDetails
site_idSWS_FT_FI18
Number of Residues16
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"32641835","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6V9V","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI19
Number of Residues24
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"25855297","evidenceCode":"ECO:0000305"}]}
ChainResidueDetails
site_idSWS_FT_FI20
Number of Residues4
DetailsSite: {"description":"Required for C-621 reactivity","evidences":[{"source":"PubMed","id":"27241698","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI21
Number of Residues4
DetailsSite: {"description":"Essential for electrophile activation. Sensor for electrophilic agents","evidences":[{"source":"PubMed","id":"31866091","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"32641835","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI22
Number of Residues4
DetailsSite: {"description":"Key residue for activation by the scorpion wasabi receptor toxin","evidences":[{"source":"PubMed","id":"31447178","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI23
Number of Residues8
DetailsSite: {"description":"Important residue for activation by the scorpion wasabi receptor toxin","evidences":[{"source":"PubMed","id":"31447178","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI24
Number of Residues4
DetailsSite: {"description":"Important for electrophile activation","evidences":[{"source":"PubMed","id":"31866091","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"32641835","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI25
Number of Residues4
DetailsSite: {"description":"Crucial for calcium permeation","evidences":[{"source":"UniProtKB","id":"Q6RI86","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI26
Number of Residues8
DetailsModified residue: {"description":"Cysteine sulfenic acid (-SOH); transient; in hyperoxia","evidences":[{"source":"PubMed","id":"21873995","evidenceCode":"ECO:0000305"}]}
ChainResidueDetails
site_idSWS_FT_FI27
Number of Residues8
DetailsGlycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}]}
ChainResidueDetails

247536

PDB entries from 2026-01-14

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