6PPZ

Crystal structure of NeuB, an N-acetylneuraminate synthase from Neisseria meningitidis, in complex with manganese, inorganic phosphate, and N-acetylmannosamine (NeuB.Mn2+.Pi.ManNAc)

Summary for 6PPZ

Entry DOI	10.2210/pdb6ppz/pdb
Descriptor	N-acetylneuraminate synthase, 2-(ACETYLAMINO)-2-DEOXY-D-MANNOSE, MANGANESE (II) ION, ... (5 entities in total)
Functional Keywords	neub, sialic acid synthase, siac, n-acetylneuraminate synthase, phosphate, n-acetylmannosamine, transferase, biosynthetic protein
Biological source	Neisseria meningitidis serogroup B
Total number of polymer chains	1
Total formula weight	38766.85
Authors	Berti, P.J.,Junop, M.S. (deposition date: 2019-07-08, release date: 2019-10-02, Last modification date: 2023-10-11)
Primary citation	Popovic, V.,Morrison, E.,Rosanally, A.Z.,Balachandran, N.,Senson, A.W.,Szabla, R.,Junop, M.S.,Berti, P.J. NeuNAc Oxime: A Slow-Binding and Effectively Irreversible Inhibitor of the Sialic Acid Synthase NeuB. Biochemistry, 58:4236-4245, 2019 Cited by PubMed: 31549502 DOI: 10.1021/acs.biochem.9b00654 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.4 Å)

Structure validation