6PNX

Crystal Structure of an Asymmetric Dimer of FGF Receptor 3 Kinases Trapped in A-loop Tyrosine Transphosphorylation Reaction

6PNX の概要

• エントリーDOI: 10.2210/pdb6pnx/pdb
• 分子名称: Fibroblast growth factor receptor 3, PHOSPHOMETHYLPHOSPHONIC ACID ADENYLATE ESTER, SULFATE ION, ... (4 entities in total)
• 機能のキーワード: tyrosine kinase, transphosphorylation, asymmetric dimer, transferase
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 74290.25

構造登録者

Mohammadi, M. (登録日: 2019-07-03, 公開日: 2020-01-22, 最終更新日: 2023-10-11)

• 主引用文献: Chen, L.,Marsiglia, W.M.,Chen, H.,Katigbak, J.,Erdjument-Bromage, H.,Kemble, D.J.,Fu, L.,Ma, J.,Sun, G.,Zhang, Y.,Liang, G.,Neubert, T.A.,Li, X.,Traaseth, N.J.,Mohammadi, M.; Molecular basis for receptor tyrosine kinase A-loop tyrosine transphosphorylation.; Nat.Chem.Biol., 16:267-277, 2020; PubMed: 31959966; DOI: 10.1038/s41589-019-0455-7

実験手法

X-RAY DIFFRACTION (2.199 Å)