6PKX

Cryo-EM structure of the zebrafish TRPM2 channel in the presence of ADPR and Ca2+

Summary for 6PKX

Entry DOI	10.2210/pdb6pkx/pdb
EMDB information	20367 20368 20369
Descriptor	Transient receptor potential cation channel subfamily M member 2, CALCIUM ION, [(2R,3S,4R,5R)-5-(6-AMINOPURIN-9-YL)-3,4-DIHYDROXY-OXOLAN-2-YL]METHYL [HYDROXY-[[(2R,3S,4R,5S)-3,4,5-TRIHYDROXYOXOLAN-2-YL]METHOXY]PHOSPHORYL] HYDROGEN PHOSPHATE (3 entities in total)
Functional Keywords	warmth sensor, redox sensor, calcium-permeable ion channel, trp channel, trpm channel, ion channel, adp-ribose, transport protein
Biological source	Danio rerio (Zebrafish)
Total number of polymer chains	4
Total formula weight	671633.29
Authors	Yin, Y.,Wu, M.,Hsu, A.L.,Borschel, W.F.,Borgnia, M.J.,Lander, G.C.,Lee, S.-Y. (deposition date: 2019-06-30, release date: 2019-08-28, Last modification date: 2019-12-18)
Primary citation	Yin, Y.,Wu, M.,Hsu, A.L.,Borschel, W.F.,Borgnia, M.J.,Lander, G.C.,Lee, S.Y. Visualizing structural transitions of ligand-dependent gating of the TRPM2 channel. Nat Commun, 10:3740-3740, 2019 Cited by PubMed: 31431622 DOI: 10.1038/s41467-019-11733-5 PDB entries with the same primary citation
Experimental method	ELECTRON MICROSCOPY (4.2 Å)

Structure validation