6PH6
Ternary complex crystal structure of DNA polymerase Beta with 2nt-gap with dCTP bound downstream
Summary for 6PH6
Entry DOI | 10.2210/pdb6ph6/pdb |
Descriptor | DNA polymerase beta, DNA (5'-D(*CP*CP*GP*AP*CP*GP*GP*CP*GP*CP*AP*TP*CP*AP*GP*C)-3'), DNA (5'-D(*GP*CP*TP*GP*AP*TP*GP*CP*G)-3'), ... (8 entities in total) |
Functional Keywords | dna polymerase beta, conformational change, enzyme mechanism, misalignment mutagenesis, transcription-dna complex, transcription/dna |
Biological source | Homo sapiens (Human) More |
Total number of polymer chains | 4 |
Total formula weight | 47980.43 |
Authors | Batra, V.K.,Wilson, S.H. (deposition date: 2019-06-25, release date: 2019-12-11, Last modification date: 2023-10-11) |
Primary citation | Howard, M.J.,Cavanaugh, N.A.,Batra, V.K.,Shock, D.D.,Beard, W.A.,Wilson, S.H. DNA polymerase beta nucleotide-stabilized template misalignment fidelity depends on local sequence context. J.Biol.Chem., 295:529-538, 2020 Cited by PubMed: 31801827DOI: 10.1074/jbc.RA119.010594 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.6 Å) |
Structure validation
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