6PFM
Crystal structure of GDC-0927 bound to estrogen receptor alpha
Summary for 6PFM
Entry DOI | 10.2210/pdb6pfm/pdb |
Related | 6PET |
Descriptor | Estrogen receptor, (2S)-2-(4-{2-[3-(fluoromethyl)azetidin-1-yl]ethoxy}phenyl)-3-(3-hydroxyphenyl)-4-methyl-2H-1-benzopyran-6-ol (3 entities in total) |
Functional Keywords | antagonist, breast cancer, ligand, nuclear protein |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 2 |
Total formula weight | 64883.64 |
Authors | Kiefer, J.R.,Vinogradova, M.,Liang, J.,Zhang, B.,Wang, X.,Zbieg, J.R.,Labadie, S.S.,Li, J.,Ray, N.C.,Ortwine, D. (deposition date: 2019-06-21, release date: 2019-07-17, Last modification date: 2024-03-13) |
Primary citation | Labadie, S.S.,Li, J.,Blake, R.A.,Chang, J.H.,Goodacre, S.,Hartman, S.J.,Liang, W.,Kiefer, J.R.,Kleinheinz, T.,Lai, T.,Liao, J.,Ortwine, D.F.,Mody, V.,Ray, N.C.,Roussel, F.,Vinogradova, M.,Yeap, S.K.,Zhang, B.,Zheng, X.,Zbieg, J.R.,Liang, J.,Wang, X. Discovery of a C-8 hydroxychromene as a potent degrader of estrogen receptor alpha with improved rat oral exposure over GDC-0927. Bioorg.Med.Chem.Lett., 29:2090-2093, 2019 Cited by PubMed: 31311734DOI: 10.1016/j.bmcl.2019.07.013 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.84 Å) |
Structure validation
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