6PFM
Crystal structure of GDC-0927 bound to estrogen receptor alpha
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 14 |
| Details | binding site for residue OGJ D 601 |
| Chain | Residue |
| D | MET343 |
| D | PHE404 |
| D | MET421 |
| D | GLY521 |
| D | HIS524 |
| D | LEU525 |
| D | LEU346 |
| D | ALA350 |
| D | ASP351 |
| D | GLU353 |
| D | LEU354 |
| D | TRP383 |
| D | LEU387 |
| D | ARG394 |
| site_id | AC2 |
| Number of Residues | 14 |
| Details | binding site for residue OGJ A 601 |
| Chain | Residue |
| A | LEU346 |
| A | ALA350 |
| A | ASP351 |
| A | GLU353 |
| A | LEU387 |
| A | LEU391 |
| A | ARG394 |
| A | PHE404 |
| A | MET421 |
| A | LEU428 |
| A | GLY521 |
| A | HIS524 |
| A | LEU525 |
| D | PRO535 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 6 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"9338790","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"9600906","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1A52","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1ERE","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"Phosphotyrosine; by Tyr-kinases","evidences":[{"source":"PubMed","id":"7539106","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | Lipidation: {"description":"S-palmitoyl cysteine","evidences":[{"evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
