6PE6

PANK3 complex structure with compound PZ-3022

Summary for 6PE6

Entry DOI	10.2210/pdb6pe6/pdb
Descriptor	Pantothenate kinase 3, 6-{4-[(4-cyclopropylphenyl)acetyl]piperazin-1-yl}pyridazine-3-carbonitrile, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, ... (5 entities in total)
Functional Keywords	pank, substrate, complex, transferase, pantothenate kinase
Biological source	Homo sapiens (Human)
Total number of polymer chains	1
Total formula weight	43003.67
Authors	White, S.W.,Yun, M. (deposition date: 2019-06-20, release date: 2020-12-23, Last modification date: 2023-10-11)
Primary citation	Subramanian, C.,Frank, M.W.,Tangallapally, R.,Yun, M.K.,Edwards, A.,White, S.W.,Lee, R.E.,Rock, C.O.,Jackowski, S. Pantothenate kinase activation relieves coenzyme A sequestration and improves mitochondrial function in mice with propionic acidemia. Sci Transl Med, 13:eabf5965-eabf5965, 2021 Cited by PubMed: 34524863 DOI: 10.1126/scitranslmed.abf5965 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.6 Å)

Structure validation