6PC4
Tubulin-RB3_SLD-TTL in complex with compound ABI-274
Summary for 6PC4
Entry DOI | 10.2210/pdb6pc4/pdb |
Related | 6AGK |
Descriptor | Tubulin alpha-1B chain, [2-(4-methylphenyl)-1H-imidazol-4-yl](3,4,5-trimethoxyphenyl)methanone, Tubulin beta-2B chain, ... (11 entities in total) |
Functional Keywords | microtubule inhibitor, colchicine, cancer, cell cycle |
Biological source | Homo sapiens (Human) More |
Total number of polymer chains | 6 |
Total formula weight | 264486.05 |
Authors | Kumar, G.,Wang, Y.,Li, W.,White, S.W. (deposition date: 2019-06-15, release date: 2020-04-22, Last modification date: 2024-03-13) |
Primary citation | Chen, H.,Deng, S.,Wang, Y.,Albadari, N.,Kumar, G.,Ma, D.,Li, W.,White, S.W.,Miller, D.D.,Li, W. Structure-Activity Relationship Study of Novel 6-Aryl-2-benzoyl-pyridines as Tubulin Polymerization Inhibitors with Potent Antiproliferative Properties. J.Med.Chem., 63:827-846, 2020 Cited by PubMed: 31860298DOI: 10.1021/acs.jmedchem.9b01815 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.602 Å) |
Structure validation
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