6PBO

Staphylococcus aureus Dihydrofolate reductase in complex with NADPH and UCP1232

Summary for 6PBO

• Entry DOI: 10.2210/pdb6pbo/pdb
• Related: 6P9Z
• Descriptor: Dihydrofolate reductase, (4-{6-[(2S)-4-(2,4-diamino-6-ethylpyrimidin-5-yl)but-3-yn-2-yl]-2H-1,3-benzodioxol-4-yl}phenyl)acetic acid, Tricyclic NADPH, ... (5 entities in total)
• Functional Keywords: dhfr, methotrexate, antifolate, nadph, antimicrobial protein
• Biological source: Staphylococcus aureus
• Total number of polymer chains: 1
• Total formula weight: 19948.86

Authors

Reeve, S.M.,Wright, D.L. (deposition date: 2019-06-14, release date: 2019-10-23, Last modification date: 2023-10-11)

• Primary citation: Reeve, S.M.,Si, D.,Krucinska, J.,Yan, Y.,Viswanathan, K.,Wang, S.,Holt, G.T.,Frenkel, M.S.,Ojewole, A.A.,Estrada, A.,Agabiti, S.S.,Alverson, J.B.,Gibson, N.D.,Priestley, N.D.,Wiemer, A.J.,Donald, B.R.,Wright, D.L.; Toward Broad Spectrum Dihydrofolate Reductase Inhibitors Targeting Trimethoprim Resistant Enzymes Identified in Clinical Isolates of Methicillin ResistantStaphylococcus aureus.; Acs Infect Dis., 5:1896-1906, 2019; PubMed: 31565920; DOI: 10.1021/acsinfecdis.9b00222

Experimental method

X-RAY DIFFRACTION (1.649 Å)