6PAY
Structure of HsICDH1:Mg(II):ICT:NADPH(50%) complex reveals structural basis for observation of half-sites reactivity
Summary for 6PAY
Entry DOI | 10.2210/pdb6pay/pdb |
Descriptor | Isocitrate dehydrogenase [NADP] cytoplasmic, ISOCITRIC ACID, MAGNESIUM ION, ... (6 entities in total) |
Functional Keywords | substrate complex, half-sites reactivity, icdh mechanism, oxidoreductase |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 4 |
Total formula weight | 188814.20 |
Authors | Silvaggi, N.R.,Melkonian, T.R.,Roman, J.V.,Moran, G.R. (deposition date: 2019-06-12, release date: 2019-09-18, Last modification date: 2023-10-11) |
Primary citation | Roman, J.V.,Melkonian, T.R.,Silvaggi, N.R.,Moran, G.R. Transient-State Analysis of Human Isocitrate Dehydrogenase I: Accounting for the Interconversion of Active and Non-Active Conformational States. Biochemistry, 58:5366-5380, 2019 Cited by PubMed: 31478653DOI: 10.1021/acs.biochem.9b00518 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.199 Å) |
Structure validation
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