6PAY

Structure of HsICDH1:Mg(II):ICT:NADPH(50%) complex reveals structural basis for observation of half-sites reactivity

6PAY の概要

• エントリーDOI: 10.2210/pdb6pay/pdb
• 分子名称: Isocitrate dehydrogenase [NADP] cytoplasmic, ISOCITRIC ACID, MAGNESIUM ION, ... (6 entities in total)
• 機能のキーワード: substrate complex, half-sites reactivity, icdh mechanism, oxidoreductase
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 188814.20

構造登録者

Silvaggi, N.R.,Melkonian, T.R.,Roman, J.V.,Moran, G.R. (登録日: 2019-06-12, 公開日: 2019-09-18, 最終更新日: 2023-10-11)

• 主引用文献: Roman, J.V.,Melkonian, T.R.,Silvaggi, N.R.,Moran, G.R.; Transient-State Analysis of Human Isocitrate Dehydrogenase I: Accounting for the Interconversion of Active and Non-Active Conformational States.; Biochemistry, 58:5366-5380, 2019; PubMed: 31478653; DOI: 10.1021/acs.biochem.9b00518

実験手法

X-RAY DIFFRACTION (2.199 Å)