6P9Z

Staphylococcus aureus Dihydrofolate reductase in complex with NADPH and Methotrexate

6P9Z の概要

• エントリーDOI: 10.2210/pdb6p9z/pdb
• 分子名称: Dihydrofolate reductase, METHOTREXATE, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ... (5 entities in total)
• 機能のキーワード: dhfr, methotrexate, antifolate, nadph, antimicrobial protein, oxidoreductase
• 由来する生物種: Staphylococcus aureus
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 19305.49

構造登録者

Reeve, S.M.,Wright, D.L. (登録日: 2019-06-10, 公開日: 2019-10-23, 最終更新日: 2023-10-11)

• 主引用文献: Reeve, S.M.,Si, D.,Krucinska, J.,Yan, Y.,Viswanathan, K.,Wang, S.,Holt, G.T.,Frenkel, M.S.,Ojewole, A.A.,Estrada, A.,Agabiti, S.S.,Alverson, J.B.,Gibson, N.D.,Priestley, N.D.,Wiemer, A.J.,Donald, B.R.,Wright, D.L.; Toward Broad Spectrum Dihydrofolate Reductase Inhibitors Targeting Trimethoprim Resistant Enzymes Identified in Clinical Isolates of Methicillin ResistantStaphylococcus aureus.; Acs Infect Dis., 5:1896-1906, 2019; PubMed: 31565920; DOI: 10.1021/acsinfecdis.9b00222

実験手法

X-RAY DIFFRACTION (1.86 Å)