6P9A

HIV-1 Protease multiple mutant PRS5B with Darunavir

Summary for 6P9A

• Entry DOI: 10.2210/pdb6p9a/pdb
• Related: 2IEN
• Descriptor: HIV-1 Protease, PHOSPHATE ION, (3R,3AS,6AR)-HEXAHYDROFURO[2,3-B]FURAN-3-YL(1S,2R)-3-[[(4-AMINOPHENYL)SULFONYL](ISOBUTYL)AMINO]-1-BENZYL-2-HYDROXYPROPYLCARBAMATE, ... (4 entities in total)
• Functional Keywords: protease, inhibitor, multiple mutant, hydrolase-hydrolase inhibitor, viral protein complex, hydrolase/hydrolase inhibitor, viral protein
• Biological source: Human immunodeficiency virus type 1 group M subtype B (isolate BRU/LAI) (HIV-1)
• Total number of polymer chains: 2
• Total formula weight: 22368.66

Authors

Kneller, D.W.,Agniswamy, J.,Weber, I.T. (deposition date: 2019-06-10, release date: 2020-04-15, Last modification date: 2023-10-11)

• Primary citation: Kneller, D.W.,Agniswamy, J.,Harrison, R.W.,Weber, I.T.; Highly drug-resistant HIV-1 protease reveals decreased intra-subunit interactions due to clusters of mutations.; Febs J., 287:3235-3254, 2020; PubMed: 31920003; DOI: 10.1111/febs.15207

Experimental method

X-RAY DIFFRACTION (1.66 Å)