6P6D

HUMAN IGG1 FC FRAGMENT, C239 INSERTION MUTANT

6P6D の概要

• エントリーDOI: 10.2210/pdb6p6d/pdb
• 関連するPDBエントリー: 5vgp
• 分子名称: IgG1 Fc fragment, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, CYSTEINE, ... (4 entities in total)
• 機能のキーワード: antibody-drug conjugate, cysteine insertion mutant, cysteine disulfide adduct, immune system
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 54601.34

構造登録者

Gallagher, D.T.,Dimasi, N.,McCullough, C. (登録日: 2019-06-03, 公開日: 2020-04-15, 最終更新日: 2023-10-11)

• 主引用文献: Gallagher, D.T.,McCullough, C.,Brinson, R.G.,Ahn, J.,Marino, J.P.,Dimasi, N.; Structure and Dynamics of a Site-Specific Labeled Fc Fragment with Altered Effector Functions.; Pharmaceutics, 11:-, 2019; PubMed: 31640157; DOI: 10.3390/pharmaceutics11100546

実験手法

X-RAY DIFFRACTION (2.31 Å)