6P4B
HyHEL10 fab variant HyHEL10-4x (heavy chain mutations L4F, Y33H, S56N, and Y58F) bound to hen egg lysozyme variant HEL2x-flex (mutations R21Q, R73E, C76S, and C94S)
Summary for 6P4B
Entry DOI | 10.2210/pdb6p4b/pdb |
Descriptor | HyHEL10 Fab light chain, HyHEL10 Fab heavy chain, Lysozyme C, ... (5 entities in total) |
Functional Keywords | hel2x-flex, hyhel10-4x, fab, antigen-antibody, hydrolase-immune system complex, hydrolase/immune system |
Biological source | Mus musculus (Mouse) More |
Total number of polymer chains | 6 |
Total formula weight | 124604.40 |
Authors | Langley, D.B.,Christ, D. (deposition date: 2019-05-27, release date: 2020-05-27, Last modification date: 2023-10-11) |
Primary citation | Burnett, D.L.,Schofield, P.,Langley, D.B.,Jackson, J.,Bourne, K.,Wilson, E.,Porebski, B.T.,Buckle, A.M.,Brink, R.,Goodnow, C.C.,Christ, D. Conformational diversity facilitates antibody mutation trajectories and discrimination between foreign and self-antigens. Proc.Natl.Acad.Sci.USA, 117:22341-22350, 2020 Cited by PubMed: 32855302DOI: 10.1073/pnas.2005102117 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.9 Å) |
Structure validation
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