6P4B

HyHEL10 fab variant HyHEL10-4x (heavy chain mutations L4F, Y33H, S56N, and Y58F) bound to hen egg lysozyme variant HEL2x-flex (mutations R21Q, R73E, C76S, and C94S)

6P4B の概要

• エントリーDOI: 10.2210/pdb6p4b/pdb
• 分子名称: HyHEL10 Fab light chain, HyHEL10 Fab heavy chain, Lysozyme C, ... (5 entities in total)
• 機能のキーワード: hel2x-flex, hyhel10-4x, fab, antigen-antibody, hydrolase-immune system complex, hydrolase/immune system
• 由来する生物種: Mus musculus (Mouse); 詳細
• タンパク質・核酸の鎖数: 6
• 化学式量合計: 124604.40

構造登録者

Langley, D.B.,Christ, D. (登録日: 2019-05-27, 公開日: 2020-05-27, 最終更新日: 2023-10-11)

• 主引用文献: Burnett, D.L.,Schofield, P.,Langley, D.B.,Jackson, J.,Bourne, K.,Wilson, E.,Porebski, B.T.,Buckle, A.M.,Brink, R.,Goodnow, C.C.,Christ, D.; Conformational diversity facilitates antibody mutation trajectories and discrimination between foreign and self-antigens.; Proc.Natl.Acad.Sci.USA, 117:22341-22350, 2020; PubMed: 32855302; DOI: 10.1073/pnas.2005102117

実験手法

X-RAY DIFFRACTION (1.9 Å)